RF01 | PMON168 Hedgehog-Induced Somatostatin Receptor Expression is Inhibited by the Activation of the Glucocorticoid Receptor Signaling Pathway in Human Pituitary Adenoma Organoids

BACKGROUND: Cushing's disease (CD) is an endocrine disorder caused by an ACTH-secreting pituitary adenoma that is associated with increased morbidity and mortality. Because somatostatin inhibits pituitary ACTH secretion, the somatostatin receptor subtypes (SSTR) 2 and 5 have been targets of med...

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Detalles Bibliográficos
Autores principales: Zavros, Yana, Mallick, Saptarshi, Chakrabarti, Jayati, Churko, Jared, Pandey, Ritu, Eschbacher, Jennifer, Moraitis, Andreas G, Greenstein, Andrew, Little, Andrew, Yuen, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Neuroendocrinology and Pituitary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625674/
http://dx.doi.org/10.1210/jendso/bvac150.1195

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