ODP486 Hypothyroidism And Its Relation To Clinical Outcome In Covid-19 Inpatients

Thyroid dysfunction associated with Coronavirus infection (COVID-19) such as thyroiditis and sick euthyroid syndrome have been reported in recent studies, but the role of hypothyroidism in disease progression and severity remains uncertain. Our aim was to assess the frequency of hypothyroidism and its relationship with clinical outcome in patients hospitalized for COVID-19. The study was retrospective and observational with a cohort of 966 patients hospitalized for COVID-19 infection from February to August 2021, separated into two groups, with and without previous hypothyroidism, and compared in relation to the following variables: age, index of body mass (BMI), type of care, gender, initial hospitalization sector, comorbidities, requirement mechanical ventilation (MV), oxygen supplementation (O2), levothyroxine dose, thyrostimulating hormone (TSH) and free thyroxine (T4L) levels, total length of hospital stay and death. Of the 966 patients evaluated, 87 (9%) had hypothyroidism prior to hospital admission. Patients with hypothyroidism were on average 6.5 years older and had a significantly greater mean age than those without hypothyroidism. The outcome of death was evidenced in 38% of the total sample, with no statistically significant difference between the groups. In uni and multivariate analysis groups matched for sex, age and comorbidities, only older age (increase of 1.8% for each year) and the need for mechanical ventilation (increase of 9.5 times) were associated with a higher risk of death,with no impact of hypothyroidism in requirement mechanical ventilation, oxygen supplementation (O2), total length of hospital stay and death. Presentation: No date and time listed