OR17-1 MKRN3 Inhibits the Reproductive Axis by Interacting With Key Hypothalamic Substrates and Targeting Neurokinin B to Degradation Pathways.

BACKGROUND AND OBJECTIVES: Human fertility is attained following puberty due to finely orchestrated events driven by hypothalamic release of the excitatory neuropeptide neurokinin B (NKB), which in turn stimulates the release of kisspeptin and then GnRH to activate the downstream pituitary-gonadal a...

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Detalles Bibliográficos
Autores principales: Abreu, Ana Paula, Carroll, Rona S, Haase, Jacob, Kaiser, Ursula B, Landa, Iñigo, Magnotto, John C, Naulé, Lydie, Zoghdan, Manar, Mancini, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Pediatric Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625755/
http://dx.doi.org/10.1210/jendso/bvac150.1277

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