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PMON53 Resistance to weight gain and obesity in mice lacking the IGF-1 receptor in GHRH neurons
IGF-1 signaling plays a pivotal role in regulating GH production through a negative feedback mechanism at the level of the hypothalamus and pituitary. We created a transgenic mouse model with ablation of the IGF-1R in GHRH-neurons (GIGFRKO) that exhibited normal linear growth, however, when fed a no...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625820/ http://dx.doi.org/10.1210/jendso/bvac150.1153 |