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Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model
Recently, a new variant lineage of SARS-CoV-2, namely Omicron, became the dominant global circulating strain. The multiple antigenic mutations of Omicron largely decrease the efficiency of current vaccines and neutralizing antibodies, which highlights the need for more potent and reachable medical c...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625844/ https://www.ncbi.nlm.nih.gov/pubmed/36338435 http://dx.doi.org/10.1016/j.isci.2022.105475 |
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author | Yuan, Lunzhi Zhu, Huachen Zhou, Ming Ma, Jian Liu, Xuan Wu, Kun Ye, Jianghui Yu, Huan Chen, Peiwen Chen, Rirong Wang, Jia Zhang, Yali Ge, Shengxiang Yuan, Quan Cheng, Tong Guan, Yi Xia, Ningshao |
author_facet | Yuan, Lunzhi Zhu, Huachen Zhou, Ming Ma, Jian Liu, Xuan Wu, Kun Ye, Jianghui Yu, Huan Chen, Peiwen Chen, Rirong Wang, Jia Zhang, Yali Ge, Shengxiang Yuan, Quan Cheng, Tong Guan, Yi Xia, Ningshao |
author_sort | Yuan, Lunzhi |
collection | PubMed |
description | Recently, a new variant lineage of SARS-CoV-2, namely Omicron, became the dominant global circulating strain. The multiple antigenic mutations of Omicron largely decrease the efficiency of current vaccines and neutralizing antibodies, which highlights the need for more potent and reachable medical countermeasures. Here, we hypothesize that direct viral clearance by nasal irrigation might be a convenient and alternative option, and perform proof-of-concept experiments in the Syrian hamster model. Interestingly, Omicron shows a different dynamic in the changes of viral RNA, viral titers, and proinflammatory cytokines in nasal rinsing samples when compared with the prototype. Meanwhile, the levels of viral load and proinflammatory cytokines in nasal rinsing samples can indicate the severity of lung injury. Of note, daily nasal irrigation efficiently attenuates inflammation and lung injury in Omicron-infected hamsters by decreasing the viral loads in the respiratory tract organs. Moreover, daily nasal irrigation effectively suppresses viral transmission by close contact. |
format | Online Article Text |
id | pubmed-9625844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96258442022-11-02 Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model Yuan, Lunzhi Zhu, Huachen Zhou, Ming Ma, Jian Liu, Xuan Wu, Kun Ye, Jianghui Yu, Huan Chen, Peiwen Chen, Rirong Wang, Jia Zhang, Yali Ge, Shengxiang Yuan, Quan Cheng, Tong Guan, Yi Xia, Ningshao iScience Article Recently, a new variant lineage of SARS-CoV-2, namely Omicron, became the dominant global circulating strain. The multiple antigenic mutations of Omicron largely decrease the efficiency of current vaccines and neutralizing antibodies, which highlights the need for more potent and reachable medical countermeasures. Here, we hypothesize that direct viral clearance by nasal irrigation might be a convenient and alternative option, and perform proof-of-concept experiments in the Syrian hamster model. Interestingly, Omicron shows a different dynamic in the changes of viral RNA, viral titers, and proinflammatory cytokines in nasal rinsing samples when compared with the prototype. Meanwhile, the levels of viral load and proinflammatory cytokines in nasal rinsing samples can indicate the severity of lung injury. Of note, daily nasal irrigation efficiently attenuates inflammation and lung injury in Omicron-infected hamsters by decreasing the viral loads in the respiratory tract organs. Moreover, daily nasal irrigation effectively suppresses viral transmission by close contact. Elsevier 2022-11-02 /pmc/articles/PMC9625844/ /pubmed/36338435 http://dx.doi.org/10.1016/j.isci.2022.105475 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yuan, Lunzhi Zhu, Huachen Zhou, Ming Ma, Jian Liu, Xuan Wu, Kun Ye, Jianghui Yu, Huan Chen, Peiwen Chen, Rirong Wang, Jia Zhang, Yali Ge, Shengxiang Yuan, Quan Cheng, Tong Guan, Yi Xia, Ningshao Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model |
title | Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model |
title_full | Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model |
title_fullStr | Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model |
title_full_unstemmed | Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model |
title_short | Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model |
title_sort | nasal irrigation efficiently attenuates sars-cov-2 omicron infection, transmission and lung injury in the syrian hamster model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625844/ https://www.ncbi.nlm.nih.gov/pubmed/36338435 http://dx.doi.org/10.1016/j.isci.2022.105475 |
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