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Clinical outcomes associated with Mu variant infection during the third epidemic peak of COVID-19 in Colombia
BACKGROUND: The higher number of cases and deaths caused by COVID-19 in Colombia occurred during the third epidemic peak, where the Mu variant was associated with 50% of the cases. OBJECTIVE: To evaluate the association between the clinical outcome of COVID-19 with health conditions and SARS-CoV-2 l...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625851/ https://www.ncbi.nlm.nih.gov/pubmed/36332905 http://dx.doi.org/10.1016/j.ijid.2022.10.028 |
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author | Álvarez-Díaz, Diego A. Ruiz-Moreno, Hector A. Zapata-Bedoya, Silvana Franco-Muñoz, Carlos Laiton-Donato, Katherine Ferro, Carolina Sepulveda, Maria T. Herrera Pacheco-Montealegre, Mauricio Walteros, Diana M. Carrero-Galindo, Laura C. Mercado-Reyes, Marcela |
author_facet | Álvarez-Díaz, Diego A. Ruiz-Moreno, Hector A. Zapata-Bedoya, Silvana Franco-Muñoz, Carlos Laiton-Donato, Katherine Ferro, Carolina Sepulveda, Maria T. Herrera Pacheco-Montealegre, Mauricio Walteros, Diana M. Carrero-Galindo, Laura C. Mercado-Reyes, Marcela |
author_sort | Álvarez-Díaz, Diego A. |
collection | PubMed |
description | BACKGROUND: The higher number of cases and deaths caused by COVID-19 in Colombia occurred during the third epidemic peak, where the Mu variant was associated with 50% of the cases. OBJECTIVE: To evaluate the association between the clinical outcome of COVID-19 with health conditions and SARS-CoV-2 lineages. METHODS: In this study, clinical metadata and SARS-CoV-2 lineages from 535 patients with different degrees of COVID-19 severity were obtained after the SARS-CoV-2 genomic surveillance in Colombia. Then, the associations between these variables were determined using a multidimensional unfolding analysis. RESULTS: Asymptomatic, symptomatic, severe, and deceased outcomes represented 15.2%, 29.7%, 7.3%, and 47.8% of the cases, respectively. Males tend to develop more serious COVID-19, and severe or fatal outcomes were typically observed in patients aged >60 years with comorbidities, including chronic obstructive pulmonary disease, heart disease, kidney disease, obesity, asthma, and smoking history. The SARS-CoV-2 Mu and Gamma variants dominated the third epidemic peak and accounted for most fatal cases with odd ratio values of 128.2 (CI 53.0-310.1) and 18.6 (CI 8.294-41.917). CONCLUSION: This study shows the high impact of SARS-CoV-2 lineages with higher prevalence on public health and the importance of monitoring COVID-19 risk factors to control the associated mortality. |
format | Online Article Text |
id | pubmed-9625851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96258512022-11-02 Clinical outcomes associated with Mu variant infection during the third epidemic peak of COVID-19 in Colombia Álvarez-Díaz, Diego A. Ruiz-Moreno, Hector A. Zapata-Bedoya, Silvana Franco-Muñoz, Carlos Laiton-Donato, Katherine Ferro, Carolina Sepulveda, Maria T. Herrera Pacheco-Montealegre, Mauricio Walteros, Diana M. Carrero-Galindo, Laura C. Mercado-Reyes, Marcela Int J Infect Dis Article BACKGROUND: The higher number of cases and deaths caused by COVID-19 in Colombia occurred during the third epidemic peak, where the Mu variant was associated with 50% of the cases. OBJECTIVE: To evaluate the association between the clinical outcome of COVID-19 with health conditions and SARS-CoV-2 lineages. METHODS: In this study, clinical metadata and SARS-CoV-2 lineages from 535 patients with different degrees of COVID-19 severity were obtained after the SARS-CoV-2 genomic surveillance in Colombia. Then, the associations between these variables were determined using a multidimensional unfolding analysis. RESULTS: Asymptomatic, symptomatic, severe, and deceased outcomes represented 15.2%, 29.7%, 7.3%, and 47.8% of the cases, respectively. Males tend to develop more serious COVID-19, and severe or fatal outcomes were typically observed in patients aged >60 years with comorbidities, including chronic obstructive pulmonary disease, heart disease, kidney disease, obesity, asthma, and smoking history. The SARS-CoV-2 Mu and Gamma variants dominated the third epidemic peak and accounted for most fatal cases with odd ratio values of 128.2 (CI 53.0-310.1) and 18.6 (CI 8.294-41.917). CONCLUSION: This study shows the high impact of SARS-CoV-2 lineages with higher prevalence on public health and the importance of monitoring COVID-19 risk factors to control the associated mortality. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022-12 2022-11-02 /pmc/articles/PMC9625851/ /pubmed/36332905 http://dx.doi.org/10.1016/j.ijid.2022.10.028 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Álvarez-Díaz, Diego A. Ruiz-Moreno, Hector A. Zapata-Bedoya, Silvana Franco-Muñoz, Carlos Laiton-Donato, Katherine Ferro, Carolina Sepulveda, Maria T. Herrera Pacheco-Montealegre, Mauricio Walteros, Diana M. Carrero-Galindo, Laura C. Mercado-Reyes, Marcela Clinical outcomes associated with Mu variant infection during the third epidemic peak of COVID-19 in Colombia |
title | Clinical outcomes associated with Mu variant infection during the third epidemic peak of COVID-19 in Colombia |
title_full | Clinical outcomes associated with Mu variant infection during the third epidemic peak of COVID-19 in Colombia |
title_fullStr | Clinical outcomes associated with Mu variant infection during the third epidemic peak of COVID-19 in Colombia |
title_full_unstemmed | Clinical outcomes associated with Mu variant infection during the third epidemic peak of COVID-19 in Colombia |
title_short | Clinical outcomes associated with Mu variant infection during the third epidemic peak of COVID-19 in Colombia |
title_sort | clinical outcomes associated with mu variant infection during the third epidemic peak of covid-19 in colombia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625851/ https://www.ncbi.nlm.nih.gov/pubmed/36332905 http://dx.doi.org/10.1016/j.ijid.2022.10.028 |
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