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Adaptation criterion for segmentectomy in small‐sized early stage non‐small cell lung cancer
BACKGROUND: Although the utility of segmentectomy for early‐stage non‐small cell lung cancer (NSCLC) has been reported, the adaptation criterion for segmentectomy is unclear. METHODS: In total, 171 NSCLC patients who underwent segmentectomy or lobectomy with a consolidation tumor diameter on compute...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626306/ https://www.ncbi.nlm.nih.gov/pubmed/36165084 http://dx.doi.org/10.1111/1759-7714.14647 |
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author | Motono, Nozomu Mizoguchi, Takaki Ishikawa, Masahito Iwai, Shun Iijima, Yoshihito Uramoto, Hidetaka |
author_facet | Motono, Nozomu Mizoguchi, Takaki Ishikawa, Masahito Iwai, Shun Iijima, Yoshihito Uramoto, Hidetaka |
author_sort | Motono, Nozomu |
collection | PubMed |
description | BACKGROUND: Although the utility of segmentectomy for early‐stage non‐small cell lung cancer (NSCLC) has been reported, the adaptation criterion for segmentectomy is unclear. METHODS: In total, 171 NSCLC patients who underwent segmentectomy or lobectomy with a consolidation tumor diameter on computed tomography of ≤20 mm were analyzed. RESULTS: Consolidation diameter (p = 0.01), consolidation to tumor ratio (CTR) (p < 0.01), maximum standardized uptake value (SUV(max)) (p < 0.01), and segmentectomy (p = 0.01) were significantly different upon univariate analysis among patients stratified by recurrence. Positive correlations were observed between the consolidation diameter on CT and CEA (correlation coefficient; r = 0.19, p = 0.01), SUV(max) (r = 0.48, p < 0.01), and CTR (r = 0.83, p < 0.01). Because there was a significant correlation among the consolidation diameter of tumors on CT, CTR, and SUV(max) in this study, we integrated these factors into one. Consolidation, CTR, and SUV(max) (hazard ratio [HR]: 3.77, 95% confidence interval [CI]: 1.35–11.29, p = 0.01) and segmentectomy (HR: 0.24, 95% CI: 0.03–0.90, p = 0.03) were risk factors for recurrence in a multivariate analysis. There was a significant difference between the segmentectomy and lobectomy groups (5‐year relapse‐free survival [RFS] 96.5% vs. 80.7%, p = 0.02). CONCLUSIONS: Consolidation tumor diameter on CT, CTR, and SUV(max) is a risk factor for recurrence. These results suggest that for patients with small‐sized early stage NSCLC, this combined factor is important for determining the indication for segmentectomy. |
format | Online Article Text |
id | pubmed-9626306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-96263062022-11-03 Adaptation criterion for segmentectomy in small‐sized early stage non‐small cell lung cancer Motono, Nozomu Mizoguchi, Takaki Ishikawa, Masahito Iwai, Shun Iijima, Yoshihito Uramoto, Hidetaka Thorac Cancer Original Articles BACKGROUND: Although the utility of segmentectomy for early‐stage non‐small cell lung cancer (NSCLC) has been reported, the adaptation criterion for segmentectomy is unclear. METHODS: In total, 171 NSCLC patients who underwent segmentectomy or lobectomy with a consolidation tumor diameter on computed tomography of ≤20 mm were analyzed. RESULTS: Consolidation diameter (p = 0.01), consolidation to tumor ratio (CTR) (p < 0.01), maximum standardized uptake value (SUV(max)) (p < 0.01), and segmentectomy (p = 0.01) were significantly different upon univariate analysis among patients stratified by recurrence. Positive correlations were observed between the consolidation diameter on CT and CEA (correlation coefficient; r = 0.19, p = 0.01), SUV(max) (r = 0.48, p < 0.01), and CTR (r = 0.83, p < 0.01). Because there was a significant correlation among the consolidation diameter of tumors on CT, CTR, and SUV(max) in this study, we integrated these factors into one. Consolidation, CTR, and SUV(max) (hazard ratio [HR]: 3.77, 95% confidence interval [CI]: 1.35–11.29, p = 0.01) and segmentectomy (HR: 0.24, 95% CI: 0.03–0.90, p = 0.03) were risk factors for recurrence in a multivariate analysis. There was a significant difference between the segmentectomy and lobectomy groups (5‐year relapse‐free survival [RFS] 96.5% vs. 80.7%, p = 0.02). CONCLUSIONS: Consolidation tumor diameter on CT, CTR, and SUV(max) is a risk factor for recurrence. These results suggest that for patients with small‐sized early stage NSCLC, this combined factor is important for determining the indication for segmentectomy. John Wiley & Sons Australia, Ltd 2022-09-27 2022-11 /pmc/articles/PMC9626306/ /pubmed/36165084 http://dx.doi.org/10.1111/1759-7714.14647 Text en © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Motono, Nozomu Mizoguchi, Takaki Ishikawa, Masahito Iwai, Shun Iijima, Yoshihito Uramoto, Hidetaka Adaptation criterion for segmentectomy in small‐sized early stage non‐small cell lung cancer |
title | Adaptation criterion for segmentectomy in small‐sized early stage non‐small cell lung cancer |
title_full | Adaptation criterion for segmentectomy in small‐sized early stage non‐small cell lung cancer |
title_fullStr | Adaptation criterion for segmentectomy in small‐sized early stage non‐small cell lung cancer |
title_full_unstemmed | Adaptation criterion for segmentectomy in small‐sized early stage non‐small cell lung cancer |
title_short | Adaptation criterion for segmentectomy in small‐sized early stage non‐small cell lung cancer |
title_sort | adaptation criterion for segmentectomy in small‐sized early stage non‐small cell lung cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626306/ https://www.ncbi.nlm.nih.gov/pubmed/36165084 http://dx.doi.org/10.1111/1759-7714.14647 |
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