Cargando…
Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size
BACKGROUND: Consolidation tumor ratio (CTR) calculated as the ratio of the tumor consolidation diameter to the tumor maximum diameter on thin‐section computed tomography (CT) of lung cancer has been reported as an important prognostic factor. It has also been used for treatment decision‐making. This...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626346/ https://www.ncbi.nlm.nih.gov/pubmed/36193574 http://dx.doi.org/10.1111/1759-7714.14653 |
_version_ | 1784822711175872512 |
---|---|
author | Koike, Sachie Shimizu, Kimihiro Ide, Shogo Mishima, Shuji Matsuoka, Shunichiro Takeda, Tetsu Miura, Kentaro Eguchi, Takashi Hamanaka, Kazutoshi Araki, Taisuke Sonehara, Kei Todoroki, Keisuke Ichinohe, Fumihito Kawakami, Satoshi Koinuma, Masayoshi |
author_facet | Koike, Sachie Shimizu, Kimihiro Ide, Shogo Mishima, Shuji Matsuoka, Shunichiro Takeda, Tetsu Miura, Kentaro Eguchi, Takashi Hamanaka, Kazutoshi Araki, Taisuke Sonehara, Kei Todoroki, Keisuke Ichinohe, Fumihito Kawakami, Satoshi Koinuma, Masayoshi |
author_sort | Koike, Sachie |
collection | PubMed |
description | BACKGROUND: Consolidation tumor ratio (CTR) calculated as the ratio of the tumor consolidation diameter to the tumor maximum diameter on thin‐section computed tomography (CT) of lung cancer has been reported as an important prognostic factor. It has also been used for treatment decision‐making. This study aimed to investigate the interobserver variability of CTR measurements on preoperative CT and propose a clinically useful CTR‐based classification criterion. METHODS: We enrolled 119 patients who underwent surgery for suspected or diagnosed small‐sized lung cancer (≤3.0 cm in diameter). Nine doctors reviewed preoperative CT scans to measure CTR. Interobserver variability of CTR measurements was evaluated using the coefficient of variation (CV) and Fleiss' κ. The prognostic effect of the CTR‐based classification was assessed using the Kaplan–Meier method. RESULTS: Interobserver variability of CTR measurement was the highest for tumors with the lowest CTR (CTR = 0); it decreased as CTR increased and reached a plateaued level of low variability (CV <0.5) at CTR of 0.5. We proposed a three‐group classification based on the findings of CTR interobserver variability (CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1). Interobserver agreement of the judgment of the CTR‐based classification was excellent (Fleiss' κ = 0.81). The classification significantly stratified patient prognosis (p < 0.001, 5‐year overall survival rates with CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1 were 100, 88, and 73.8%, respectively). CONCLUSIONS: CTR 0.5 is a clinically relevant and helpful cutoff for treatment decision‐making in patients with early‐stage lung cancer based on high interobserver agreement and good prognostic stratification. |
format | Online Article Text |
id | pubmed-9626346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-96263462022-11-03 Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size Koike, Sachie Shimizu, Kimihiro Ide, Shogo Mishima, Shuji Matsuoka, Shunichiro Takeda, Tetsu Miura, Kentaro Eguchi, Takashi Hamanaka, Kazutoshi Araki, Taisuke Sonehara, Kei Todoroki, Keisuke Ichinohe, Fumihito Kawakami, Satoshi Koinuma, Masayoshi Thorac Cancer Original Articles BACKGROUND: Consolidation tumor ratio (CTR) calculated as the ratio of the tumor consolidation diameter to the tumor maximum diameter on thin‐section computed tomography (CT) of lung cancer has been reported as an important prognostic factor. It has also been used for treatment decision‐making. This study aimed to investigate the interobserver variability of CTR measurements on preoperative CT and propose a clinically useful CTR‐based classification criterion. METHODS: We enrolled 119 patients who underwent surgery for suspected or diagnosed small‐sized lung cancer (≤3.0 cm in diameter). Nine doctors reviewed preoperative CT scans to measure CTR. Interobserver variability of CTR measurements was evaluated using the coefficient of variation (CV) and Fleiss' κ. The prognostic effect of the CTR‐based classification was assessed using the Kaplan–Meier method. RESULTS: Interobserver variability of CTR measurement was the highest for tumors with the lowest CTR (CTR = 0); it decreased as CTR increased and reached a plateaued level of low variability (CV <0.5) at CTR of 0.5. We proposed a three‐group classification based on the findings of CTR interobserver variability (CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1). Interobserver agreement of the judgment of the CTR‐based classification was excellent (Fleiss' κ = 0.81). The classification significantly stratified patient prognosis (p < 0.001, 5‐year overall survival rates with CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1 were 100, 88, and 73.8%, respectively). CONCLUSIONS: CTR 0.5 is a clinically relevant and helpful cutoff for treatment decision‐making in patients with early‐stage lung cancer based on high interobserver agreement and good prognostic stratification. John Wiley & Sons Australia, Ltd 2022-10-03 2022-11 /pmc/articles/PMC9626346/ /pubmed/36193574 http://dx.doi.org/10.1111/1759-7714.14653 Text en © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Koike, Sachie Shimizu, Kimihiro Ide, Shogo Mishima, Shuji Matsuoka, Shunichiro Takeda, Tetsu Miura, Kentaro Eguchi, Takashi Hamanaka, Kazutoshi Araki, Taisuke Sonehara, Kei Todoroki, Keisuke Ichinohe, Fumihito Kawakami, Satoshi Koinuma, Masayoshi Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size |
title | Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size |
title_full | Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size |
title_fullStr | Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size |
title_full_unstemmed | Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size |
title_short | Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size |
title_sort | is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626346/ https://www.ncbi.nlm.nih.gov/pubmed/36193574 http://dx.doi.org/10.1111/1759-7714.14653 |
work_keys_str_mv | AT koikesachie isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT shimizukimihiro isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT ideshogo isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT mishimashuji isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT matsuokashunichiro isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT takedatetsu isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT miurakentaro isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT eguchitakashi isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT hamanakakazutoshi isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT arakitaisuke isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT soneharakei isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT todorokikeisuke isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT ichinohefumihito isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT kawakamisatoshi isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize AT koinumamasayoshi isusingaconsolidationtumorratio05ascriterionfeasibleindailypracticeevaluationofinterobservermeasurementvariabilityofconsolidationtumorratiooflungcancerlessthan3cminsize |