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Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size

BACKGROUND: Consolidation tumor ratio (CTR) calculated as the ratio of the tumor consolidation diameter to the tumor maximum diameter on thin‐section computed tomography (CT) of lung cancer has been reported as an important prognostic factor. It has also been used for treatment decision‐making. This...

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Autores principales: Koike, Sachie, Shimizu, Kimihiro, Ide, Shogo, Mishima, Shuji, Matsuoka, Shunichiro, Takeda, Tetsu, Miura, Kentaro, Eguchi, Takashi, Hamanaka, Kazutoshi, Araki, Taisuke, Sonehara, Kei, Todoroki, Keisuke, Ichinohe, Fumihito, Kawakami, Satoshi, Koinuma, Masayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626346/
https://www.ncbi.nlm.nih.gov/pubmed/36193574
http://dx.doi.org/10.1111/1759-7714.14653
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author Koike, Sachie
Shimizu, Kimihiro
Ide, Shogo
Mishima, Shuji
Matsuoka, Shunichiro
Takeda, Tetsu
Miura, Kentaro
Eguchi, Takashi
Hamanaka, Kazutoshi
Araki, Taisuke
Sonehara, Kei
Todoroki, Keisuke
Ichinohe, Fumihito
Kawakami, Satoshi
Koinuma, Masayoshi
author_facet Koike, Sachie
Shimizu, Kimihiro
Ide, Shogo
Mishima, Shuji
Matsuoka, Shunichiro
Takeda, Tetsu
Miura, Kentaro
Eguchi, Takashi
Hamanaka, Kazutoshi
Araki, Taisuke
Sonehara, Kei
Todoroki, Keisuke
Ichinohe, Fumihito
Kawakami, Satoshi
Koinuma, Masayoshi
author_sort Koike, Sachie
collection PubMed
description BACKGROUND: Consolidation tumor ratio (CTR) calculated as the ratio of the tumor consolidation diameter to the tumor maximum diameter on thin‐section computed tomography (CT) of lung cancer has been reported as an important prognostic factor. It has also been used for treatment decision‐making. This study aimed to investigate the interobserver variability of CTR measurements on preoperative CT and propose a clinically useful CTR‐based classification criterion. METHODS: We enrolled 119 patients who underwent surgery for suspected or diagnosed small‐sized lung cancer (≤3.0 cm in diameter). Nine doctors reviewed preoperative CT scans to measure CTR. Interobserver variability of CTR measurements was evaluated using the coefficient of variation (CV) and Fleiss' κ. The prognostic effect of the CTR‐based classification was assessed using the Kaplan–Meier method. RESULTS: Interobserver variability of CTR measurement was the highest for tumors with the lowest CTR (CTR = 0); it decreased as CTR increased and reached a plateaued level of low variability (CV <0.5) at CTR of 0.5. We proposed a three‐group classification based on the findings of CTR interobserver variability (CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1). Interobserver agreement of the judgment of the CTR‐based classification was excellent (Fleiss' κ = 0.81). The classification significantly stratified patient prognosis (p < 0.001, 5‐year overall survival rates with CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1 were 100, 88, and 73.8%, respectively). CONCLUSIONS: CTR 0.5 is a clinically relevant and helpful cutoff for treatment decision‐making in patients with early‐stage lung cancer based on high interobserver agreement and good prognostic stratification.
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spelling pubmed-96263462022-11-03 Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size Koike, Sachie Shimizu, Kimihiro Ide, Shogo Mishima, Shuji Matsuoka, Shunichiro Takeda, Tetsu Miura, Kentaro Eguchi, Takashi Hamanaka, Kazutoshi Araki, Taisuke Sonehara, Kei Todoroki, Keisuke Ichinohe, Fumihito Kawakami, Satoshi Koinuma, Masayoshi Thorac Cancer Original Articles BACKGROUND: Consolidation tumor ratio (CTR) calculated as the ratio of the tumor consolidation diameter to the tumor maximum diameter on thin‐section computed tomography (CT) of lung cancer has been reported as an important prognostic factor. It has also been used for treatment decision‐making. This study aimed to investigate the interobserver variability of CTR measurements on preoperative CT and propose a clinically useful CTR‐based classification criterion. METHODS: We enrolled 119 patients who underwent surgery for suspected or diagnosed small‐sized lung cancer (≤3.0 cm in diameter). Nine doctors reviewed preoperative CT scans to measure CTR. Interobserver variability of CTR measurements was evaluated using the coefficient of variation (CV) and Fleiss' κ. The prognostic effect of the CTR‐based classification was assessed using the Kaplan–Meier method. RESULTS: Interobserver variability of CTR measurement was the highest for tumors with the lowest CTR (CTR = 0); it decreased as CTR increased and reached a plateaued level of low variability (CV <0.5) at CTR of 0.5. We proposed a three‐group classification based on the findings of CTR interobserver variability (CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1). Interobserver agreement of the judgment of the CTR‐based classification was excellent (Fleiss' κ = 0.81). The classification significantly stratified patient prognosis (p < 0.001, 5‐year overall survival rates with CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1 were 100, 88, and 73.8%, respectively). CONCLUSIONS: CTR 0.5 is a clinically relevant and helpful cutoff for treatment decision‐making in patients with early‐stage lung cancer based on high interobserver agreement and good prognostic stratification. John Wiley & Sons Australia, Ltd 2022-10-03 2022-11 /pmc/articles/PMC9626346/ /pubmed/36193574 http://dx.doi.org/10.1111/1759-7714.14653 Text en © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Koike, Sachie
Shimizu, Kimihiro
Ide, Shogo
Mishima, Shuji
Matsuoka, Shunichiro
Takeda, Tetsu
Miura, Kentaro
Eguchi, Takashi
Hamanaka, Kazutoshi
Araki, Taisuke
Sonehara, Kei
Todoroki, Keisuke
Ichinohe, Fumihito
Kawakami, Satoshi
Koinuma, Masayoshi
Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size
title Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size
title_full Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size
title_fullStr Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size
title_full_unstemmed Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size
title_short Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size
title_sort is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626346/
https://www.ncbi.nlm.nih.gov/pubmed/36193574
http://dx.doi.org/10.1111/1759-7714.14653
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