Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

The pyrin inflammasome acts as a guard of RhoA GTPases and is central to immune defenses against RhoA-manipulating pathogens. Pyrin activation proceeds in two steps. Yet, the second step is still poorly understood. Using cells constitutively activated for the pyrin step 1, a chemical screen identifi...

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Detalles Bibliográficos
Autores principales: Magnotti, Flora, Chirita, Daria, Dalmon, Sarah, Martin, Amandine, Bronnec, Pauline, Sousa, Jeremy, Helynck, Olivier, Lee, Wonyong, Kastner, Daniel L., Chae, Jae Jin, McDermott, Michael F., Belot, Alexandre, Popoff, Michel, Sève, Pascal, Georgin-Lavialle, Sophie, Munier-Lehmann, Hélène, Tran, Tu Anh, De Langhe, Ellen, Wouters, Carine, Jamilloux, Yvan, Henry, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626387/
https://www.ncbi.nlm.nih.gov/pubmed/36223753
http://dx.doi.org/10.1016/j.celrep.2022.111472

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