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Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation

The number of patients waiting for heart transplantation (HTX) is increasing. Thus, identification of outcome-relevant factors is crucial. This study aimed to identify perioperative factors associated with days alive and out of hospital (DAOH)—a patient-centered outcome to quantify life impact—after...

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Autores principales: M’Pembele, René, Roth, Sebastian, Stroda, Alexandra, Reier, Tilman, Lurati Buse, Giovanna, Sixt, Stephan U., Westenfeld, Ralf, Rellecke, Philipp, Tudorache, Igor, Hollmann, Markus W., Aubin, Hug, Akhyari, Payam, Lichtenberg, Artur, Huhn, Ragnar, Boeken, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626454/
https://www.ncbi.nlm.nih.gov/pubmed/36319821
http://dx.doi.org/10.1038/s41598-022-21936-4
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author M’Pembele, René
Roth, Sebastian
Stroda, Alexandra
Reier, Tilman
Lurati Buse, Giovanna
Sixt, Stephan U.
Westenfeld, Ralf
Rellecke, Philipp
Tudorache, Igor
Hollmann, Markus W.
Aubin, Hug
Akhyari, Payam
Lichtenberg, Artur
Huhn, Ragnar
Boeken, Udo
author_facet M’Pembele, René
Roth, Sebastian
Stroda, Alexandra
Reier, Tilman
Lurati Buse, Giovanna
Sixt, Stephan U.
Westenfeld, Ralf
Rellecke, Philipp
Tudorache, Igor
Hollmann, Markus W.
Aubin, Hug
Akhyari, Payam
Lichtenberg, Artur
Huhn, Ragnar
Boeken, Udo
author_sort M’Pembele, René
collection PubMed
description The number of patients waiting for heart transplantation (HTX) is increasing. Thus, identification of outcome-relevant factors is crucial. This study aimed to identify perioperative factors associated with days alive and out of hospital (DAOH)—a patient-centered outcome to quantify life impact—after HTX. This retrospective cohort study screened 187 patients who underwent HTX at university hospital Duesseldorf, Germany from September 2010 to December 2020. The primary endpoint was DAOH at 1 year. Risk factors for mortality after HTX were assessed in univariate analysis. Variables with significant association were entered into multivariable quantile regression. In total, 175 patients were included into analysis. Median DAOH at 1 year was 295 (223–322) days. In univariate analysis the following variables were associated with reduced DAOH: recipient or donor diabetes pre-HTX, renal replacement therapy (RRT), VA-ECMO therapy, recipient body mass index, recipient estimated glomerular filtration rate (eGFR) and postoperative duration of mechanical ventilation. After adjustment, mechanical ventilation, RRT, eGFR and recipient diabetes showed significant independent association with DAOH. This study identified risk factors associated with reduced DAOH at 1-year after HTX. These findings might complement existing data for outcome of patients undergoing HTX.
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spelling pubmed-96264542022-11-03 Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation M’Pembele, René Roth, Sebastian Stroda, Alexandra Reier, Tilman Lurati Buse, Giovanna Sixt, Stephan U. Westenfeld, Ralf Rellecke, Philipp Tudorache, Igor Hollmann, Markus W. Aubin, Hug Akhyari, Payam Lichtenberg, Artur Huhn, Ragnar Boeken, Udo Sci Rep Article The number of patients waiting for heart transplantation (HTX) is increasing. Thus, identification of outcome-relevant factors is crucial. This study aimed to identify perioperative factors associated with days alive and out of hospital (DAOH)—a patient-centered outcome to quantify life impact—after HTX. This retrospective cohort study screened 187 patients who underwent HTX at university hospital Duesseldorf, Germany from September 2010 to December 2020. The primary endpoint was DAOH at 1 year. Risk factors for mortality after HTX were assessed in univariate analysis. Variables with significant association were entered into multivariable quantile regression. In total, 175 patients were included into analysis. Median DAOH at 1 year was 295 (223–322) days. In univariate analysis the following variables were associated with reduced DAOH: recipient or donor diabetes pre-HTX, renal replacement therapy (RRT), VA-ECMO therapy, recipient body mass index, recipient estimated glomerular filtration rate (eGFR) and postoperative duration of mechanical ventilation. After adjustment, mechanical ventilation, RRT, eGFR and recipient diabetes showed significant independent association with DAOH. This study identified risk factors associated with reduced DAOH at 1-year after HTX. These findings might complement existing data for outcome of patients undergoing HTX. Nature Publishing Group UK 2022-11-01 /pmc/articles/PMC9626454/ /pubmed/36319821 http://dx.doi.org/10.1038/s41598-022-21936-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
M’Pembele, René
Roth, Sebastian
Stroda, Alexandra
Reier, Tilman
Lurati Buse, Giovanna
Sixt, Stephan U.
Westenfeld, Ralf
Rellecke, Philipp
Tudorache, Igor
Hollmann, Markus W.
Aubin, Hug
Akhyari, Payam
Lichtenberg, Artur
Huhn, Ragnar
Boeken, Udo
Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation
title Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation
title_full Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation
title_fullStr Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation
title_full_unstemmed Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation
title_short Validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation
title_sort validation of days alive and out of hospital as a new patient-centered outcome to quantify life impact after heart transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626454/
https://www.ncbi.nlm.nih.gov/pubmed/36319821
http://dx.doi.org/10.1038/s41598-022-21936-4
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