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Artifact characterization and mitigation techniques during concurrent sensing and stimulation using bidirectional deep brain stimulation platforms

Bidirectional deep brain stimulation (DBS) platforms have enabled a surge in hours of recordings in naturalistic environments, allowing further insight into neurological and psychiatric disease states. However, high amplitude, high frequency stimulation generates artifacts that contaminate neural si...

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Autores principales: Alarie, Michaela E., Provenza, Nicole R., Avendano-Ortega, Michelle, McKay, Sarah A., Waite, Ayan S., Mathura, Raissa K., Herron, Jeffrey A., Sheth, Sameer A., Borton, David A., Goodman, Wayne K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626519/
https://www.ncbi.nlm.nih.gov/pubmed/36337849
http://dx.doi.org/10.3389/fnhum.2022.1016379
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author Alarie, Michaela E.
Provenza, Nicole R.
Avendano-Ortega, Michelle
McKay, Sarah A.
Waite, Ayan S.
Mathura, Raissa K.
Herron, Jeffrey A.
Sheth, Sameer A.
Borton, David A.
Goodman, Wayne K.
author_facet Alarie, Michaela E.
Provenza, Nicole R.
Avendano-Ortega, Michelle
McKay, Sarah A.
Waite, Ayan S.
Mathura, Raissa K.
Herron, Jeffrey A.
Sheth, Sameer A.
Borton, David A.
Goodman, Wayne K.
author_sort Alarie, Michaela E.
collection PubMed
description Bidirectional deep brain stimulation (DBS) platforms have enabled a surge in hours of recordings in naturalistic environments, allowing further insight into neurological and psychiatric disease states. However, high amplitude, high frequency stimulation generates artifacts that contaminate neural signals and hinder our ability to interpret the data. This is especially true in psychiatric disorders, for which high amplitude stimulation is commonly applied to deep brain structures where the native neural activity is miniscule in comparison. Here, we characterized artifact sources in recordings from a bidirectional DBS platform, the Medtronic Summit RC + S, with the goal of optimizing recording configurations to improve signal to noise ratio (SNR). Data were collected from three subjects in a clinical trial of DBS for obsessive-compulsive disorder. Stimulation was provided bilaterally to the ventral capsule/ventral striatum (VC/VS) using two independent implantable neurostimulators. We first manipulated DBS amplitude within safe limits (2–5.3 mA) to characterize the impact of stimulation artifacts on neural recordings. We found that high amplitude stimulation produces slew overflow, defined as exceeding the rate of change that the analog to digital converter can accurately measure. Overflow led to expanded spectral distortion of the stimulation artifact, with a six fold increase in the bandwidth of the 150.6 Hz stimulation artifact from 147–153 to 140–180 Hz. By increasing sense blank values during high amplitude stimulation, we reduced overflow by as much as 30% and improved artifact distortion, reducing the bandwidth from 140–180 Hz artifact to 147–153 Hz. We also identified artifacts that shifted in frequency through modulation of telemetry parameters. We found that telemetry ratio changes led to predictable shifts in the center-frequencies of the associated artifacts, allowing us to proactively shift the artifacts outside of our frequency range of interest. Overall, the artifact characterization methods and results described here enable increased data interpretability and unconstrained biomarker exploration using data collected from bidirectional DBS devices.
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spelling pubmed-96265192022-11-03 Artifact characterization and mitigation techniques during concurrent sensing and stimulation using bidirectional deep brain stimulation platforms Alarie, Michaela E. Provenza, Nicole R. Avendano-Ortega, Michelle McKay, Sarah A. Waite, Ayan S. Mathura, Raissa K. Herron, Jeffrey A. Sheth, Sameer A. Borton, David A. Goodman, Wayne K. Front Hum Neurosci Human Neuroscience Bidirectional deep brain stimulation (DBS) platforms have enabled a surge in hours of recordings in naturalistic environments, allowing further insight into neurological and psychiatric disease states. However, high amplitude, high frequency stimulation generates artifacts that contaminate neural signals and hinder our ability to interpret the data. This is especially true in psychiatric disorders, for which high amplitude stimulation is commonly applied to deep brain structures where the native neural activity is miniscule in comparison. Here, we characterized artifact sources in recordings from a bidirectional DBS platform, the Medtronic Summit RC + S, with the goal of optimizing recording configurations to improve signal to noise ratio (SNR). Data were collected from three subjects in a clinical trial of DBS for obsessive-compulsive disorder. Stimulation was provided bilaterally to the ventral capsule/ventral striatum (VC/VS) using two independent implantable neurostimulators. We first manipulated DBS amplitude within safe limits (2–5.3 mA) to characterize the impact of stimulation artifacts on neural recordings. We found that high amplitude stimulation produces slew overflow, defined as exceeding the rate of change that the analog to digital converter can accurately measure. Overflow led to expanded spectral distortion of the stimulation artifact, with a six fold increase in the bandwidth of the 150.6 Hz stimulation artifact from 147–153 to 140–180 Hz. By increasing sense blank values during high amplitude stimulation, we reduced overflow by as much as 30% and improved artifact distortion, reducing the bandwidth from 140–180 Hz artifact to 147–153 Hz. We also identified artifacts that shifted in frequency through modulation of telemetry parameters. We found that telemetry ratio changes led to predictable shifts in the center-frequencies of the associated artifacts, allowing us to proactively shift the artifacts outside of our frequency range of interest. Overall, the artifact characterization methods and results described here enable increased data interpretability and unconstrained biomarker exploration using data collected from bidirectional DBS devices. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9626519/ /pubmed/36337849 http://dx.doi.org/10.3389/fnhum.2022.1016379 Text en Copyright © 2022 Alarie, Provenza, Avendano-Ortega, McKay, Waite, Mathura, Herron, Sheth, Borton and Goodman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Alarie, Michaela E.
Provenza, Nicole R.
Avendano-Ortega, Michelle
McKay, Sarah A.
Waite, Ayan S.
Mathura, Raissa K.
Herron, Jeffrey A.
Sheth, Sameer A.
Borton, David A.
Goodman, Wayne K.
Artifact characterization and mitigation techniques during concurrent sensing and stimulation using bidirectional deep brain stimulation platforms
title Artifact characterization and mitigation techniques during concurrent sensing and stimulation using bidirectional deep brain stimulation platforms
title_full Artifact characterization and mitigation techniques during concurrent sensing and stimulation using bidirectional deep brain stimulation platforms
title_fullStr Artifact characterization and mitigation techniques during concurrent sensing and stimulation using bidirectional deep brain stimulation platforms
title_full_unstemmed Artifact characterization and mitigation techniques during concurrent sensing and stimulation using bidirectional deep brain stimulation platforms
title_short Artifact characterization and mitigation techniques during concurrent sensing and stimulation using bidirectional deep brain stimulation platforms
title_sort artifact characterization and mitigation techniques during concurrent sensing and stimulation using bidirectional deep brain stimulation platforms
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626519/
https://www.ncbi.nlm.nih.gov/pubmed/36337849
http://dx.doi.org/10.3389/fnhum.2022.1016379
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