Cargando…

The therapeutic potential of triptolide and celastrol in neurological diseases

Neurological diseases are complex diseases affecting the brain and spinal cord, with numerous etiologies and pathogenesis not yet fully elucidated. Tripterygium wilfordii Hook. F. (TWHF) is a traditional Chinese medicine with a long history of medicinal use in China and is widely used to treat autoi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Yueran, Jiang, Xuejiao, Feng, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626530/ https://www.ncbi.nlm.nih.gov/pubmed/36339550 http://dx.doi.org/10.3389/fphar.2022.1024955

Ejemplares similares

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
por: Chen, Shao-Ru, et al.
Publicado: (2018)

Therapeutic Potential of Triptolide in Treating Bone-Related Disorders
por: Gang, Wu, et al.
Publicado: (2022)

Nanotechnology-Based Celastrol Formulations and Their Therapeutic Applications
por: Wagh, Pushkaraj Rajendra, et al.
Publicado: (2021)

Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review
por: Yuan, Kai, et al.
Publicado: (2019)

Celastrol and Triptolide Suppress Stemness in Triple Negative Breast Cancer: Notch as a Therapeutic Target for Stem Cells
por: Ramamoorthy, Prabhu, et al.
Publicado: (2021)

Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I
por: Zhao, Qian, et al.
Publicado: (2015)

The molecular pathogenesis of triptolide-induced hepatotoxicity
por: Hu, Yeqing, et al.
Publicado: (2022)

Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine
por: Jiang, Qi-Wei, et al.
Publicado: (2015)

Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms
por: Li, Mengzhen, et al.
Publicado: (2022)

CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of Tripterygium wilfordii
por: Jin, Chunhuan, et al.
Publicado: (2019)

Macrophage malfunction in Triptolide-induced indirect hepatotoxicity
por: Qin, Tingting, et al.
Publicado: (2022)

Celastrol Attenuates Multiple Sclerosis and Optic Neuritis in an Experimental Autoimmune Encephalomyelitis Model
por: Yang, Hongbin, et al.
Publicado: (2017)

Identifying the Effect of Celastrol Against Ovarian Cancer With Network Pharmacology and In Vitro Experiments
por: Wang, Xuan, et al.
Publicado: (2022)

Celastrol inhibits store operated calcium entry and suppresses psoriasis
por: Yuan, Xiaoman, et al.
Publicado: (2023)

Effect of Adoptive Transfer or Depletion of Regulatory T Cells on Triptolide-induced Liver Injury
por: Wang, Xinzhi, et al.
Publicado: (2016)

The Efficacy of Triptolide in Preventing Diabetic Kidney Diseases: A Systematic Review and Meta-Analysis
por: Liang, Dongning, et al.
Publicado: (2021)

Potential Target Analysis of Triptolide Based on Transcriptome-Wide m(6)A Methylome in Rheumatoid Arthritis
por: Fan, Danping, et al.
Publicado: (2022)

Effect of the Natural Product Triptolide on Pancreatic Cancer: A Systematic Review of Preclinical Studies
por: Zhang, Chi, et al.
Publicado: (2017)

Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases
por: Maramai, Samuele, et al.
Publicado: (2016)

The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy
por: Yan, Min, et al.
Publicado: (2022)

Triptolide Attenuates Vascular Calcification by Upregulating Expression of miRNA-204
por: Pei, Yu-qiang, et al.
Publicado: (2021)

Triptolide Induces Leydig Cell Apoptosis by Disrupting Mitochondrial Dynamics in Rats
por: Lv, Linyan, et al.
Publicado: (2021)

Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats
por: Yang, Jing, et al.
Publicado: (2017)

SHP2 inhibition improves celastrol-induced growth suppression of colorectal cancer
por: Zhang, Linxi, et al.
Publicado: (2022)

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
por: Shi, Jinfeng, et al.
Publicado: (2020)

Effect of Triptolide on Temporal Expression of Cell Cycle Regulators During Cardiac Hypertrophy
por: Li, Jing-Mei, et al.
Publicado: (2020)

Celastrol Alleviates Airway Hyperresponsiveness and Inhibits Th17 Responses in Obese Asthmatic Mice
por: Zeng, Zeyu, et al.
Publicado: (2018)

Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability
por: Zhou, Bo, et al.
Publicado: (2021)

Effect of Triptolide on Dextran Sodium Sulfate-Induced Ulcerative Colitis and Gut Microbiota in Mice
por: Wu, Hao, et al.
Publicado: (2020)

Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy
por: Ding, Yuan-Yuan, et al.
Publicado: (2016)

Potential therapeutics against neurological disorders: Natural products-based drugs
por: Rauf, Abdur, et al.
Publicado: (2022)

Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway
por: Yang, Guangxia, et al.
Publicado: (2022)

Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes
por: Liu, Chenshu, et al.
Publicado: (2023)

Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity
por: Cheng, Yaxin, et al.
Publicado: (2021)

Editorial: Erythropoietin and Its Analogues as Therapeutics for Neurological Diseases
por: Brines, Michael, et al.
Publicado: (2022)

Celastrol Inhibited Human Esophageal Cancer by Activating DR5-Dependent Extrinsic and Noxa/Bim-Dependent Intrinsic Apoptosis
por: Chen, Xihui, et al.
Publicado: (2022)

Editorial: Assessing the Pharmacological Effects and Therapeutic Potential of Traditional Chinese Medicine in Neurological Disease Models: An Update
por: Deng, Zhiqiang, et al.
Publicado: (2022)

Editorial: Natural Products-Based Drugs: Potential Therapeutics Against Alzheimer’s Disease and Other Neurological Disorders
por: Ayaz, Muhammad, et al.
Publicado: (2019)

Editorial: Natural products in the treatment of neurological diseases: identification of novel active compounds and therapeutic targets
por: Zhao, Jia, et al.
Publicado: (2023)

A Bibliometric Analysis of Triptolide and the Recent Advances in Treating Non–Small Cell Lung Cancer
por: Yang, Quancheng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hgrst02bqsvnjen3mnpikt5qc1