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Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes asymptomatic or mild symptoms, even rare hospitalization in children. A major concern is whether the pre-existing antibodies induced by low pathogenic human coronaviruses (LPH-CoVs) in children can cross-react with SARS-Co...

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Autores principales: Li, Nina, Li, XueYun, Wu, Jiani, Zhang, Shengze, Zhu, Lin, Chen, Qiqi, Fan, Ying, Wu, Zhengyu, Xie, Sidian, Chen, Qi, Wang, Ning, Wu, Nan, Luo, Chuming, Shu, Yuelong, Luo, Huanle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626651/
https://www.ncbi.nlm.nih.gov/pubmed/36341358
http://dx.doi.org/10.3389/fimmu.2022.1042406
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author Li, Nina
Li, XueYun
Wu, Jiani
Zhang, Shengze
Zhu, Lin
Chen, Qiqi
Fan, Ying
Wu, Zhengyu
Xie, Sidian
Chen, Qi
Wang, Ning
Wu, Nan
Luo, Chuming
Shu, Yuelong
Luo, Huanle
author_facet Li, Nina
Li, XueYun
Wu, Jiani
Zhang, Shengze
Zhu, Lin
Chen, Qiqi
Fan, Ying
Wu, Zhengyu
Xie, Sidian
Chen, Qi
Wang, Ning
Wu, Nan
Luo, Chuming
Shu, Yuelong
Luo, Huanle
author_sort Li, Nina
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes asymptomatic or mild symptoms, even rare hospitalization in children. A major concern is whether the pre-existing antibodies induced by low pathogenic human coronaviruses (LPH-CoVs) in children can cross-react with SARS-CoV-2. To address this unresolved question, we analyzed the pre-existing spike (S)-specific immunoglobin (Ig) G antibodies against LPH-CoVs and the cross-reactive antibodies against SARS-CoV-2 in 658 serum samples collected from children prior to SARS-CoV-2 outbreak. We found that the seroprevalence of these four LPH-CoVs reached 75.84%, and about 24.64% of the seropositive samples had cross-reactive IgG antibodies against the nucleocapsid, S, and receptor binding domain antigens of SARS-CoV-2. Additionally, the re-infections with different LPH-CoVs occurred frequently in children and tended to increase the cross-reactive antibodies against SARS-CoV-2. From the forty-nine serum samples with cross-reactive anti-S IgG antibodies against SARS-CoV-2, we found that seven samples with a median age of 1.4 years old had detected neutralizing activity for the wild-type or mutant SARS-CoV-2 S pseudotypes. Interestingly, all of the seven samples contained anti-S IgG antibodies against HCoV-OC43. Together, these data suggest that children’s pre-existing antibodies to LPH-CoVs have limited cross-reactive neutralizing antibodies against SRAS-CoV-2.
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spelling pubmed-96266512022-11-03 Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children Li, Nina Li, XueYun Wu, Jiani Zhang, Shengze Zhu, Lin Chen, Qiqi Fan, Ying Wu, Zhengyu Xie, Sidian Chen, Qi Wang, Ning Wu, Nan Luo, Chuming Shu, Yuelong Luo, Huanle Front Immunol Immunology Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes asymptomatic or mild symptoms, even rare hospitalization in children. A major concern is whether the pre-existing antibodies induced by low pathogenic human coronaviruses (LPH-CoVs) in children can cross-react with SARS-CoV-2. To address this unresolved question, we analyzed the pre-existing spike (S)-specific immunoglobin (Ig) G antibodies against LPH-CoVs and the cross-reactive antibodies against SARS-CoV-2 in 658 serum samples collected from children prior to SARS-CoV-2 outbreak. We found that the seroprevalence of these four LPH-CoVs reached 75.84%, and about 24.64% of the seropositive samples had cross-reactive IgG antibodies against the nucleocapsid, S, and receptor binding domain antigens of SARS-CoV-2. Additionally, the re-infections with different LPH-CoVs occurred frequently in children and tended to increase the cross-reactive antibodies against SARS-CoV-2. From the forty-nine serum samples with cross-reactive anti-S IgG antibodies against SARS-CoV-2, we found that seven samples with a median age of 1.4 years old had detected neutralizing activity for the wild-type or mutant SARS-CoV-2 S pseudotypes. Interestingly, all of the seven samples contained anti-S IgG antibodies against HCoV-OC43. Together, these data suggest that children’s pre-existing antibodies to LPH-CoVs have limited cross-reactive neutralizing antibodies against SRAS-CoV-2. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9626651/ /pubmed/36341358 http://dx.doi.org/10.3389/fimmu.2022.1042406 Text en Copyright © 2022 Li, Li, Wu, Zhang, Zhu, Chen, Fan, Wu, Xie, Chen, Wang, Wu, Luo, Shu and Luo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Nina
Li, XueYun
Wu, Jiani
Zhang, Shengze
Zhu, Lin
Chen, Qiqi
Fan, Ying
Wu, Zhengyu
Xie, Sidian
Chen, Qi
Wang, Ning
Wu, Nan
Luo, Chuming
Shu, Yuelong
Luo, Huanle
Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children
title Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children
title_full Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children
title_fullStr Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children
title_full_unstemmed Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children
title_short Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children
title_sort pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against sars-cov-2 in children
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626651/
https://www.ncbi.nlm.nih.gov/pubmed/36341358
http://dx.doi.org/10.3389/fimmu.2022.1042406
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