Cargando…
Severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate
Glycerol phenylbutyrate (GPB) is an ammonia scavenger drug commonly used in the therapy of patients with urea cycle defects. Reported side effects include body odor, abdominal pain, nausea, burning sensation in mouth, vomiting, and heartburn. We report on a 3‐year‐old late diagnosed female patient w...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626662/ https://www.ncbi.nlm.nih.gov/pubmed/36341170 http://dx.doi.org/10.1002/jmd2.12286 |
_version_ | 1784822786867331072 |
---|---|
author | Grünert, Sarah Catharina Schumann, Anke Spiekerkoetter, Ute |
author_facet | Grünert, Sarah Catharina Schumann, Anke Spiekerkoetter, Ute |
author_sort | Grünert, Sarah Catharina |
collection | PubMed |
description | Glycerol phenylbutyrate (GPB) is an ammonia scavenger drug commonly used in the therapy of patients with urea cycle defects. Reported side effects include body odor, abdominal pain, nausea, burning sensation in mouth, vomiting, and heartburn. We report on a 3‐year‐old late diagnosed female patient with ornithine transcarbamylase deficiency that experienced severe loss of appetite under treatment with GBP. Due to catabolism (calory intake about 400 kcal/day) and the associated risk of metabolic decompensation, GBP treatment was discontinued. Her appetite and eating behavior normalized within 1 day after discontinuation of GBP and switch to sodium benzoate. Our case demonstrates that GBP can cause severe loss of appetite that may put patients at risk of metabolic decompensation and require discontinuation of therapy. |
format | Online Article Text |
id | pubmed-9626662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96266622022-11-03 Severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate Grünert, Sarah Catharina Schumann, Anke Spiekerkoetter, Ute JIMD Rep Case Reports Glycerol phenylbutyrate (GPB) is an ammonia scavenger drug commonly used in the therapy of patients with urea cycle defects. Reported side effects include body odor, abdominal pain, nausea, burning sensation in mouth, vomiting, and heartburn. We report on a 3‐year‐old late diagnosed female patient with ornithine transcarbamylase deficiency that experienced severe loss of appetite under treatment with GBP. Due to catabolism (calory intake about 400 kcal/day) and the associated risk of metabolic decompensation, GBP treatment was discontinued. Her appetite and eating behavior normalized within 1 day after discontinuation of GBP and switch to sodium benzoate. Our case demonstrates that GBP can cause severe loss of appetite that may put patients at risk of metabolic decompensation and require discontinuation of therapy. John Wiley & Sons, Inc. 2022-09-30 /pmc/articles/PMC9626662/ /pubmed/36341170 http://dx.doi.org/10.1002/jmd2.12286 Text en © 2022 The Authors. JIMD Reports published by John Wiley & Sons Ltd on behalf of SSIEM. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Grünert, Sarah Catharina Schumann, Anke Spiekerkoetter, Ute Severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate |
title | Severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate |
title_full | Severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate |
title_fullStr | Severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate |
title_full_unstemmed | Severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate |
title_short | Severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate |
title_sort | severe loss of appetite and refusal to eat as severe side effect of glycerol phenylbutyrate |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626662/ https://www.ncbi.nlm.nih.gov/pubmed/36341170 http://dx.doi.org/10.1002/jmd2.12286 |
work_keys_str_mv | AT grunertsarahcatharina severelossofappetiteandrefusaltoeatasseveresideeffectofglycerolphenylbutyrate AT schumannanke severelossofappetiteandrefusaltoeatasseveresideeffectofglycerolphenylbutyrate AT spiekerkoetterute severelossofappetiteandrefusaltoeatasseveresideeffectofglycerolphenylbutyrate |