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Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction
BACKGROUND: There are few prospective studies assessing the benefits of rhythm control of atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF), which accounts for 50% of all heart failure patients. OBJECTIVE: Conduct a meta-analysis to assess the effects of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626734/ https://www.ncbi.nlm.nih.gov/pubmed/36340484 http://dx.doi.org/10.1016/j.hroo.2022.06.009 |
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author | Al-Sadawi, Mohammed Aleem, Saadat Aslam, Faisal Jacobs, Robin Stevens, Gregg Almasry, Ibrahim Singh, Abhijeet Fan, Roger Rashba, Eric |
author_facet | Al-Sadawi, Mohammed Aleem, Saadat Aslam, Faisal Jacobs, Robin Stevens, Gregg Almasry, Ibrahim Singh, Abhijeet Fan, Roger Rashba, Eric |
author_sort | Al-Sadawi, Mohammed |
collection | PubMed |
description | BACKGROUND: There are few prospective studies assessing the benefits of rhythm control of atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF), which accounts for 50% of all heart failure patients. OBJECTIVE: Conduct a meta-analysis to assess the effects of rhythm control (ablation and/or antiarrhythmic medications) vs rate control on all-cause mortality in AF patients with HFpEF. METHODS: Databases were searched for studies reporting the effect of rhythm control vs rate control on mortality in patients with HFpEF (Ovid MEDLINE, EMBASE, Scopus, Web of Science, Google Scholar, and EBSCO CINAHL). The search was not restricted to time or publication status. The primary endpoint was all-cause mortality. The minimum duration of follow-up required for inclusion was 1 year. RESULTS: The literature search identified 1210 candidate studies; 5 studies and 16,825 patients were included. The study population had 57% men with a mean age of 71± 2.5 years. Rhythm control for AF was associated with lower all-cause mortality (odds ratio 0.735, 95% confidence interval 0.665–0.813; P < .001) as compared to rate control. CONCLUSION: Rhythm control for AF in patients with HFpEF was associated with decreased all-cause mortality. |
format | Online Article Text |
id | pubmed-9626734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96267342022-11-03 Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction Al-Sadawi, Mohammed Aleem, Saadat Aslam, Faisal Jacobs, Robin Stevens, Gregg Almasry, Ibrahim Singh, Abhijeet Fan, Roger Rashba, Eric Heart Rhythm O2 Clinical BACKGROUND: There are few prospective studies assessing the benefits of rhythm control of atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF), which accounts for 50% of all heart failure patients. OBJECTIVE: Conduct a meta-analysis to assess the effects of rhythm control (ablation and/or antiarrhythmic medications) vs rate control on all-cause mortality in AF patients with HFpEF. METHODS: Databases were searched for studies reporting the effect of rhythm control vs rate control on mortality in patients with HFpEF (Ovid MEDLINE, EMBASE, Scopus, Web of Science, Google Scholar, and EBSCO CINAHL). The search was not restricted to time or publication status. The primary endpoint was all-cause mortality. The minimum duration of follow-up required for inclusion was 1 year. RESULTS: The literature search identified 1210 candidate studies; 5 studies and 16,825 patients were included. The study population had 57% men with a mean age of 71± 2.5 years. Rhythm control for AF was associated with lower all-cause mortality (odds ratio 0.735, 95% confidence interval 0.665–0.813; P < .001) as compared to rate control. CONCLUSION: Rhythm control for AF in patients with HFpEF was associated with decreased all-cause mortality. Elsevier 2022-06-30 /pmc/articles/PMC9626734/ /pubmed/36340484 http://dx.doi.org/10.1016/j.hroo.2022.06.009 Text en © 2022 Heart Rhythm Society. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Clinical Al-Sadawi, Mohammed Aleem, Saadat Aslam, Faisal Jacobs, Robin Stevens, Gregg Almasry, Ibrahim Singh, Abhijeet Fan, Roger Rashba, Eric Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction |
title | Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction |
title_full | Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction |
title_fullStr | Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction |
title_full_unstemmed | Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction |
title_short | Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction |
title_sort | rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction |
topic | Clinical |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626734/ https://www.ncbi.nlm.nih.gov/pubmed/36340484 http://dx.doi.org/10.1016/j.hroo.2022.06.009 |
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