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Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting

Axonal repair is critical for functional recovery after injury of the CNS. We previously reported that neuronal PTEN deletion exhibits an age-dependent decline in promoting axon regeneration from the corticospinal tract (CST). How sprouting of uninjured axons, a naturally occurring form of axonal re...

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Detalles Bibliográficos
Autores principales: Geoffroy, Cédric G., Meves, Jessica M., Kim, Hugo Jae Mun, Romaus-Sanjurjo, Daniel, Sutherland, Theresa C., Li, Jeffrey J., Suen, Juliet, Sanchez, Joshua J., Zheng, Binhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626739/
https://www.ncbi.nlm.nih.gov/pubmed/36339257
http://dx.doi.org/10.1016/j.isci.2022.105383