TNFR1 Contributes to Activation-Induced Cell Death of Pathological CD4(+) T Lymphocytes During Ischemic Heart Failure

CD4(+) T cells turn pathological during heart failure (HF). We show that the expression of tumor necrosis factor (TNF)-α and tumor necrosis factor receptor (TNFR1) increases in HF-activated CD4(+) T cells. However, the role of the TNF-α/TNFR1 axis in T-cell activation/proliferation is unknown. We sh...

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Detalles Bibliográficos
Autores principales: Kumar, Vinay, Rosenzweig, Rachel, Asalla, Suman, Nehra, Sarita, Prabhu, Sumanth D., Bansal, Shyam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626895/
https://www.ncbi.nlm.nih.gov/pubmed/36337927
http://dx.doi.org/10.1016/j.jacbts.2022.05.005

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