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Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype
Patients with established coronary artery disease remain at elevated risk of major adverse cardiac events. The goal of this study was to evaluate the utility of plasminogen activator inhibitor-1–positive platelet-derived extracellular vesicles as a biomarker for major adverse cardiac events and to e...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626902/ https://www.ncbi.nlm.nih.gov/pubmed/36337926 http://dx.doi.org/10.1016/j.jacbts.2022.05.002 |
| _version_ | 1784822835010600960 |
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| author | Jung, Richard G. Duchez, Anne-Claire Simard, Trevor Dhaliwal, Shan Gillmore, Taylor Di Santo, Pietro Labinaz, Alisha Ramirez, F. Daniel Rasheed, Adil Robichaud, Sabrina Ouimet, Mireille Short, Spencer Clifford, Cole Xiao, Fengxia Lordkipanidzé, Marie Burger, Dylan Gadde, Suresh Rayner, Katey J. Hibbert, Benjamin |
| author_facet | Jung, Richard G. Duchez, Anne-Claire Simard, Trevor Dhaliwal, Shan Gillmore, Taylor Di Santo, Pietro Labinaz, Alisha Ramirez, F. Daniel Rasheed, Adil Robichaud, Sabrina Ouimet, Mireille Short, Spencer Clifford, Cole Xiao, Fengxia Lordkipanidzé, Marie Burger, Dylan Gadde, Suresh Rayner, Katey J. Hibbert, Benjamin |
| author_sort | Jung, Richard G. |
| collection | PubMed |
| description | Patients with established coronary artery disease remain at elevated risk of major adverse cardiac events. The goal of this study was to evaluate the utility of plasminogen activator inhibitor-1–positive platelet-derived extracellular vesicles as a biomarker for major adverse cardiac events and to explore potential underlying mechanisms. Our study suggests these extracellular vesicles as a potential biomarker to identify and a therapeutic target to ameliorate neointimal formation of high-risk patients. |
| format | Online Article Text |
| id | pubmed-9626902 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96269022022-11-03 Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype Jung, Richard G. Duchez, Anne-Claire Simard, Trevor Dhaliwal, Shan Gillmore, Taylor Di Santo, Pietro Labinaz, Alisha Ramirez, F. Daniel Rasheed, Adil Robichaud, Sabrina Ouimet, Mireille Short, Spencer Clifford, Cole Xiao, Fengxia Lordkipanidzé, Marie Burger, Dylan Gadde, Suresh Rayner, Katey J. Hibbert, Benjamin JACC Basic Transl Sci Original Research - Clinical Patients with established coronary artery disease remain at elevated risk of major adverse cardiac events. The goal of this study was to evaluate the utility of plasminogen activator inhibitor-1–positive platelet-derived extracellular vesicles as a biomarker for major adverse cardiac events and to explore potential underlying mechanisms. Our study suggests these extracellular vesicles as a potential biomarker to identify and a therapeutic target to ameliorate neointimal formation of high-risk patients. Elsevier 2022-09-21 /pmc/articles/PMC9626902/ /pubmed/36337926 http://dx.doi.org/10.1016/j.jacbts.2022.05.002 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Original Research - Clinical Jung, Richard G. Duchez, Anne-Claire Simard, Trevor Dhaliwal, Shan Gillmore, Taylor Di Santo, Pietro Labinaz, Alisha Ramirez, F. Daniel Rasheed, Adil Robichaud, Sabrina Ouimet, Mireille Short, Spencer Clifford, Cole Xiao, Fengxia Lordkipanidzé, Marie Burger, Dylan Gadde, Suresh Rayner, Katey J. Hibbert, Benjamin Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype |
| title | Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype |
| title_full | Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype |
| title_fullStr | Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype |
| title_full_unstemmed | Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype |
| title_short | Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype |
| title_sort | plasminogen activator inhibitor-1–positive platelet-derived extracellular vesicles predicts mace and the proinflammatory smc phenotype |
| topic | Original Research - Clinical |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626902/ https://www.ncbi.nlm.nih.gov/pubmed/36337926 http://dx.doi.org/10.1016/j.jacbts.2022.05.002 |
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