Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists

Recent studies have reported that the peroxisome proliferator–activated receptor gamma (PPARγ) pathway is activated in approximately 40% of patients with muscle-invasive bladder cancer. This led us to investigate pharmacological repression of PPARγ as a possible intervention strategy. Here, we chara...

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Detalles Bibliográficos
Autores principales: Irwin, Sean, Karr, Craig, Furman, Craig, Tsai, Jennifer, Gee, Patricia, Banka, Deepti, Wibowo, Ardian S., Dementiev, Alexey A., O’Shea, Morgan, Yang, Joyce, Lowe, Jason, Mitchell, Lorna, Ruppel, Sabine, Fekkes, Peter, Zhu, Ping, Korpal, Manav, Larsen, Nicholas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626935/
https://www.ncbi.nlm.nih.gov/pubmed/36179791
http://dx.doi.org/10.1016/j.jbc.2022.102539

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