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Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890

Heterotrimeric G proteins couple activated G protein–coupled receptors (GPCRs) to intracellular signaling pathways. They can also function independently of GPCR activation upon acquiring mutations that prevent GTPase activity and result in constitutive signaling, as occurs with the αqQ209L mutation...

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Detalles Bibliográficos
Autores principales:	Randolph, Clinita E., Dwyer, Morgan B., Aumiller, Jenna L., Dixon, Alethia J., Inoue, Asuka, Osei-Owusu, Patrick, Wedegaertner, Philip B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626947/ https://www.ncbi.nlm.nih.gov/pubmed/36174676 http://dx.doi.org/10.1016/j.jbc.2022.102538

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