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Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study
Several MRI techniques have become available to support the early diagnosis of multiple system atrophy (MSA), but few longitudinal studies on both MSA variants have been performed, and there are no established MRI markers of disease progression. We aimed to characterize longitudinal brain changes in...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626981/ https://www.ncbi.nlm.nih.gov/pubmed/36341112 http://dx.doi.org/10.3389/fneur.2022.1017311 |
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author | Ponticorvo, Sara Manara, Renzo Russillo, Maria Claudia Andreozzi, Valentina Forino, Lorenzo Erro, Roberto Picillo, Marina Amboni, Marianna Cuoco, Sofia Di Salle, Gianfranco Di Salle, Francesco Barone, Paolo Esposito, Fabrizio Pellecchia, Maria Teresa |
author_facet | Ponticorvo, Sara Manara, Renzo Russillo, Maria Claudia Andreozzi, Valentina Forino, Lorenzo Erro, Roberto Picillo, Marina Amboni, Marianna Cuoco, Sofia Di Salle, Gianfranco Di Salle, Francesco Barone, Paolo Esposito, Fabrizio Pellecchia, Maria Teresa |
author_sort | Ponticorvo, Sara |
collection | PubMed |
description | Several MRI techniques have become available to support the early diagnosis of multiple system atrophy (MSA), but few longitudinal studies on both MSA variants have been performed, and there are no established MRI markers of disease progression. We aimed to characterize longitudinal brain changes in 26 patients with MSA (14 MSA-P and 12 MSA-C) over a 1-year follow-up period in terms of local tissue density and T1w/T2w ratio in a-priori regions, namely, bilateral putamen, cerebellar gray matter (GM), white matter (WM), and substantia nigra (SN). A significant GM density decrease was found in cerebellum and left putamen in the entire group (10.7 and 33.1% variation, respectively) and both MSA subtypes (MSA-C: 15.4 and 33.0% variation; MSA-P: 7.7 and 33.2%) and in right putamen in the entire group (19.8% variation) and patients with MSA-C (20.9% variation). A WM density decrease was found in the entire group (9.3% variation) and both subtypes in cerebellum-brainstem (MSA-C: 18.0% variation; MSA-P: 5% variation). The T1w/T2w ratio increase was found in the cerebellar and left putamen GM (6.6 and 24.9% variation), while a significant T1w/T2w ratio decrease was detected in SN in the entire MSA group (31% variation). We found a more progressive atrophy of the cerebellum in MSA-C with a similar progression of putaminal atrophy in the two variants. T1w/T2w ratio can be further studied as a potential marker of disease progression, possibly reflecting decreased neuronal density or iron accumulation. |
format | Online Article Text |
id | pubmed-9626981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96269812022-11-03 Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study Ponticorvo, Sara Manara, Renzo Russillo, Maria Claudia Andreozzi, Valentina Forino, Lorenzo Erro, Roberto Picillo, Marina Amboni, Marianna Cuoco, Sofia Di Salle, Gianfranco Di Salle, Francesco Barone, Paolo Esposito, Fabrizio Pellecchia, Maria Teresa Front Neurol Neurology Several MRI techniques have become available to support the early diagnosis of multiple system atrophy (MSA), but few longitudinal studies on both MSA variants have been performed, and there are no established MRI markers of disease progression. We aimed to characterize longitudinal brain changes in 26 patients with MSA (14 MSA-P and 12 MSA-C) over a 1-year follow-up period in terms of local tissue density and T1w/T2w ratio in a-priori regions, namely, bilateral putamen, cerebellar gray matter (GM), white matter (WM), and substantia nigra (SN). A significant GM density decrease was found in cerebellum and left putamen in the entire group (10.7 and 33.1% variation, respectively) and both MSA subtypes (MSA-C: 15.4 and 33.0% variation; MSA-P: 7.7 and 33.2%) and in right putamen in the entire group (19.8% variation) and patients with MSA-C (20.9% variation). A WM density decrease was found in the entire group (9.3% variation) and both subtypes in cerebellum-brainstem (MSA-C: 18.0% variation; MSA-P: 5% variation). The T1w/T2w ratio increase was found in the cerebellar and left putamen GM (6.6 and 24.9% variation), while a significant T1w/T2w ratio decrease was detected in SN in the entire MSA group (31% variation). We found a more progressive atrophy of the cerebellum in MSA-C with a similar progression of putaminal atrophy in the two variants. T1w/T2w ratio can be further studied as a potential marker of disease progression, possibly reflecting decreased neuronal density or iron accumulation. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9626981/ /pubmed/36341112 http://dx.doi.org/10.3389/fneur.2022.1017311 Text en Copyright © 2022 Ponticorvo, Manara, Russillo, Andreozzi, Forino, Erro, Picillo, Amboni, Cuoco, Di Salle, Di Salle, Barone, Esposito and Pellecchia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Ponticorvo, Sara Manara, Renzo Russillo, Maria Claudia Andreozzi, Valentina Forino, Lorenzo Erro, Roberto Picillo, Marina Amboni, Marianna Cuoco, Sofia Di Salle, Gianfranco Di Salle, Francesco Barone, Paolo Esposito, Fabrizio Pellecchia, Maria Teresa Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
title | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
title_full | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
title_fullStr | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
title_full_unstemmed | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
title_short | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
title_sort | combined regional t1w/t2w ratio and voxel-based morphometry in multiple system atrophy: a follow-up study |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626981/ https://www.ncbi.nlm.nih.gov/pubmed/36341112 http://dx.doi.org/10.3389/fneur.2022.1017311 |
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