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DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration

Naive B cells use the chemokine receptor CXCR5 to enter B cell follicles, where they scan CXCL13-expressing ICAM-1(+) VCAM-1(+) follicular dendritic cells (FDCs) for the presence of antigen. CXCL13-CXCR5-mediated motility is mainly driven by the Rac guanine exchange factor DOCK2, which contains a bi...

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Detalles Bibliográficos
Autores principales:	Wissmann, Stefanie, Stolp, Bettina, Jímenez, Ana Marcos, Stein, Jens V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627044/ https://www.ncbi.nlm.nih.gov/pubmed/36341455 http://dx.doi.org/10.3389/fimmu.2022.982383

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