Genetic risk score to improve prediction and treatment in gestational diabetes mellitus

Diabetes mellitus is a chronic disease caused by the interaction of genetics and the environment that can lead to chronic damage to many organ systems. Genome-wide association studies have identified accumulating single-nucleotide polymorphisms related to type 2 diabetes mellitus and gestational dia...

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Detalles Bibliográficos
Autores principales: Tian, Yumeng, Li, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627198/
https://www.ncbi.nlm.nih.gov/pubmed/36339414
http://dx.doi.org/10.3389/fendo.2022.955821
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author Tian, Yumeng
Li, Ping
author_facet Tian, Yumeng
Li, Ping
author_sort Tian, Yumeng
collection PubMed
description Diabetes mellitus is a chronic disease caused by the interaction of genetics and the environment that can lead to chronic damage to many organ systems. Genome-wide association studies have identified accumulating single-nucleotide polymorphisms related to type 2 diabetes mellitus and gestational diabetes mellitus. Genetic risk score (GRS) has been utilized to evaluate the incidence risk to improve prediction and optimize treatments. This article reviews the research progress in the use of the GRS in diabetes mellitus in recent years and discusses future prospects.
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spelling pubmed-96271982022-11-03 Genetic risk score to improve prediction and treatment in gestational diabetes mellitus Tian, Yumeng Li, Ping Front Endocrinol (Lausanne) Endocrinology Diabetes mellitus is a chronic disease caused by the interaction of genetics and the environment that can lead to chronic damage to many organ systems. Genome-wide association studies have identified accumulating single-nucleotide polymorphisms related to type 2 diabetes mellitus and gestational diabetes mellitus. Genetic risk score (GRS) has been utilized to evaluate the incidence risk to improve prediction and optimize treatments. This article reviews the research progress in the use of the GRS in diabetes mellitus in recent years and discusses future prospects. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9627198/ /pubmed/36339414 http://dx.doi.org/10.3389/fendo.2022.955821 Text en Copyright © 2022 Tian and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Tian, Yumeng
Li, Ping
Genetic risk score to improve prediction and treatment in gestational diabetes mellitus
title Genetic risk score to improve prediction and treatment in gestational diabetes mellitus
title_full Genetic risk score to improve prediction and treatment in gestational diabetes mellitus
title_fullStr Genetic risk score to improve prediction and treatment in gestational diabetes mellitus
title_full_unstemmed Genetic risk score to improve prediction and treatment in gestational diabetes mellitus
title_short Genetic risk score to improve prediction and treatment in gestational diabetes mellitus
title_sort genetic risk score to improve prediction and treatment in gestational diabetes mellitus
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627198/
https://www.ncbi.nlm.nih.gov/pubmed/36339414
http://dx.doi.org/10.3389/fendo.2022.955821
work_keys_str_mv AT tianyumeng geneticriskscoretoimprovepredictionandtreatmentingestationaldiabetesmellitus
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