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Preliminary efficacy of a digital therapeutics smartphone application for methamphetamine use disorder: An experimental study

Methamphetamine is the most widely used illicit drug in China. Treating methamphetamine use disorder (MUD) is challenging due to the lack of effective pharmacotherapies. This study is an experimental study to investigate the efficacy of smartphone-based digital therapeutics in treating MUD at the co...

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Autores principales: Zhang, Liqun, Li, Nan, Li, Yuanhui, Zhang, Tianjiao, Li, Dai, Liu, Yanru, Liu, Xiang, Hao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627209/
https://www.ncbi.nlm.nih.gov/pubmed/36339836
http://dx.doi.org/10.3389/fpsyt.2022.1027695
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author Zhang, Liqun
Li, Nan
Li, Yuanhui
Zhang, Tianjiao
Li, Dai
Liu, Yanru
Liu, Xiang
Hao, Wei
author_facet Zhang, Liqun
Li, Nan
Li, Yuanhui
Zhang, Tianjiao
Li, Dai
Liu, Yanru
Liu, Xiang
Hao, Wei
author_sort Zhang, Liqun
collection PubMed
description Methamphetamine is the most widely used illicit drug in China. Treating methamphetamine use disorder (MUD) is challenging due to the lack of effective pharmacotherapies. This study is an experimental study to investigate the efficacy of smartphone-based digital therapeutics in treating MUD at the community level. One hundred participants were recruited and randomized into a digital therapeutics (DTx) group (n = 52) and a treatment as usual (TAU) group (n = 48). The DTx group used a smartphone application to deliver cognitive behavioral therapy, approach bias modification, cognitive training, and contingency management for 8 weeks. The TAU group received counseling from social workers and professional psychotherapists. Cue-induced craving, cognitive functions, PHQ9, and GAD7 were measured at baseline and post-intervention. Wilcoxon tests were performed with bootstrap and multiply imputation to estimate the treatment effect size. The DTx group showed a significant reduction in drug craving [Wilcoxon effect size = −0.267, 95% CI = (−0.435, −0.099), p = 0.002] and a significant improvement in cognitive function [Wilcoxon effect size = 0.220, 95% CI = (0.009, 0.432), p = 0.041]. The DTx group had overall 1, 8, and 24-week attritions of 8%, 11.5%, and 38.5%, respectively. The study shows that Digital therapeutics is feasible and potentially beneficial as a complement to community substance use treatment programs.
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spelling pubmed-96272092022-11-03 Preliminary efficacy of a digital therapeutics smartphone application for methamphetamine use disorder: An experimental study Zhang, Liqun Li, Nan Li, Yuanhui Zhang, Tianjiao Li, Dai Liu, Yanru Liu, Xiang Hao, Wei Front Psychiatry Psychiatry Methamphetamine is the most widely used illicit drug in China. Treating methamphetamine use disorder (MUD) is challenging due to the lack of effective pharmacotherapies. This study is an experimental study to investigate the efficacy of smartphone-based digital therapeutics in treating MUD at the community level. One hundred participants were recruited and randomized into a digital therapeutics (DTx) group (n = 52) and a treatment as usual (TAU) group (n = 48). The DTx group used a smartphone application to deliver cognitive behavioral therapy, approach bias modification, cognitive training, and contingency management for 8 weeks. The TAU group received counseling from social workers and professional psychotherapists. Cue-induced craving, cognitive functions, PHQ9, and GAD7 were measured at baseline and post-intervention. Wilcoxon tests were performed with bootstrap and multiply imputation to estimate the treatment effect size. The DTx group showed a significant reduction in drug craving [Wilcoxon effect size = −0.267, 95% CI = (−0.435, −0.099), p = 0.002] and a significant improvement in cognitive function [Wilcoxon effect size = 0.220, 95% CI = (0.009, 0.432), p = 0.041]. The DTx group had overall 1, 8, and 24-week attritions of 8%, 11.5%, and 38.5%, respectively. The study shows that Digital therapeutics is feasible and potentially beneficial as a complement to community substance use treatment programs. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9627209/ /pubmed/36339836 http://dx.doi.org/10.3389/fpsyt.2022.1027695 Text en Copyright © 2022 Zhang, Li, Li, Zhang, Li, Liu, Liu and Hao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Zhang, Liqun
Li, Nan
Li, Yuanhui
Zhang, Tianjiao
Li, Dai
Liu, Yanru
Liu, Xiang
Hao, Wei
Preliminary efficacy of a digital therapeutics smartphone application for methamphetamine use disorder: An experimental study
title Preliminary efficacy of a digital therapeutics smartphone application for methamphetamine use disorder: An experimental study
title_full Preliminary efficacy of a digital therapeutics smartphone application for methamphetamine use disorder: An experimental study
title_fullStr Preliminary efficacy of a digital therapeutics smartphone application for methamphetamine use disorder: An experimental study
title_full_unstemmed Preliminary efficacy of a digital therapeutics smartphone application for methamphetamine use disorder: An experimental study
title_short Preliminary efficacy of a digital therapeutics smartphone application for methamphetamine use disorder: An experimental study
title_sort preliminary efficacy of a digital therapeutics smartphone application for methamphetamine use disorder: an experimental study
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627209/
https://www.ncbi.nlm.nih.gov/pubmed/36339836
http://dx.doi.org/10.3389/fpsyt.2022.1027695
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