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PMON307 Adipokines and Bone Health in Hispanic Children
INTRODUCTION: Leptin and adiponectin are adipocytokines with important metabolic functions. Leptin to adiponectin ratio is a marker of adipose tissue dysfunction and is associated with insulin resistance and cardiometabolic risk. We previously reported a negative effect of adiposity on bone health....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627247/ http://dx.doi.org/10.1210/jendso/bvac150.1291 |
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author | Shawar, Reem Ayash, Heba E Puyua, Maurice Bacha, Fida |
author_facet | Shawar, Reem Ayash, Heba E Puyua, Maurice Bacha, Fida |
author_sort | Shawar, Reem |
collection | PubMed |
description | INTRODUCTION: Leptin and adiponectin are adipocytokines with important metabolic functions. Leptin to adiponectin ratio is a marker of adipose tissue dysfunction and is associated with insulin resistance and cardiometabolic risk. We previously reported a negative effect of adiposity on bone health. We examined the relationship of adipokines to bone mass in a large cohort of Hispanic youth. We hypothesized that adipocytokine dysregulation in childhood may contribute to adverse bone health in children with obesity. METHODS: We studied 501 (237 males and 264 females) children and adolescents from the Viva la Familia Study. They were all pubertal; mean age (SD) 14.1 (2.5) years; 27% were normal weight (NW), 20% overweight (OW) and 53% obese (OB). They underwent measurement of body composition, total body less head bone mineral content (BMC) and density (BMD) by DXA scan; fasting leptin and adiponectin. The leptin to adiponectin ratio was calculated. RESULTS: Leptin concentration and leptin to adiponectin ratio were higher in OW and OB compared to NW (p<.001) whereas adiponectin was lower in OW and OB compared to NW (p<.001). After adjusting for sex, age, Tanner stage and lean mass, BMC was inversely related to leptin (r = -0.15, p =.001) and leptin to adiponectin ratio (r = -0.20, p <.001) but positively related to adiponectin (r = 0.12, p =.007). Similar relationships were found for BMD. In a regression model with BMC as the dependent variable, together and independently of sex, age, Tanner stage, lean mass and fat mass, leptin to adiponectin ratio negatively contributed (β = -0.060, p=.002) to the variance of BMC (R(2) = 0.877, p <.001). Similar findings were seen with BMD as the dependent variable. CONCLUSION: Elevated leptin to adiponectin ratio, a manifestation of adipokine dysregulation, may contribute negatively to bone health (BMC and BMD) in children with overweight/obesity. Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30 p.m. |
format | Online Article Text |
id | pubmed-9627247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-96272472022-11-03 PMON307 Adipokines and Bone Health in Hispanic Children Shawar, Reem Ayash, Heba E Puyua, Maurice Bacha, Fida J Endocr Soc Pediatric Endocrinology INTRODUCTION: Leptin and adiponectin are adipocytokines with important metabolic functions. Leptin to adiponectin ratio is a marker of adipose tissue dysfunction and is associated with insulin resistance and cardiometabolic risk. We previously reported a negative effect of adiposity on bone health. We examined the relationship of adipokines to bone mass in a large cohort of Hispanic youth. We hypothesized that adipocytokine dysregulation in childhood may contribute to adverse bone health in children with obesity. METHODS: We studied 501 (237 males and 264 females) children and adolescents from the Viva la Familia Study. They were all pubertal; mean age (SD) 14.1 (2.5) years; 27% were normal weight (NW), 20% overweight (OW) and 53% obese (OB). They underwent measurement of body composition, total body less head bone mineral content (BMC) and density (BMD) by DXA scan; fasting leptin and adiponectin. The leptin to adiponectin ratio was calculated. RESULTS: Leptin concentration and leptin to adiponectin ratio were higher in OW and OB compared to NW (p<.001) whereas adiponectin was lower in OW and OB compared to NW (p<.001). After adjusting for sex, age, Tanner stage and lean mass, BMC was inversely related to leptin (r = -0.15, p =.001) and leptin to adiponectin ratio (r = -0.20, p <.001) but positively related to adiponectin (r = 0.12, p =.007). Similar relationships were found for BMD. In a regression model with BMC as the dependent variable, together and independently of sex, age, Tanner stage, lean mass and fat mass, leptin to adiponectin ratio negatively contributed (β = -0.060, p=.002) to the variance of BMC (R(2) = 0.877, p <.001). Similar findings were seen with BMD as the dependent variable. CONCLUSION: Elevated leptin to adiponectin ratio, a manifestation of adipokine dysregulation, may contribute negatively to bone health (BMC and BMD) in children with overweight/obesity. Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30 p.m. Oxford University Press 2022-11-01 /pmc/articles/PMC9627247/ http://dx.doi.org/10.1210/jendso/bvac150.1291 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Pediatric Endocrinology Shawar, Reem Ayash, Heba E Puyua, Maurice Bacha, Fida PMON307 Adipokines and Bone Health in Hispanic Children |
title | PMON307 Adipokines and Bone Health in Hispanic Children |
title_full | PMON307 Adipokines and Bone Health in Hispanic Children |
title_fullStr | PMON307 Adipokines and Bone Health in Hispanic Children |
title_full_unstemmed | PMON307 Adipokines and Bone Health in Hispanic Children |
title_short | PMON307 Adipokines and Bone Health in Hispanic Children |
title_sort | pmon307 adipokines and bone health in hispanic children |
topic | Pediatric Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627247/ http://dx.doi.org/10.1210/jendso/bvac150.1291 |
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