Predictive Polygenic Score for Outcome after First-Line Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients Using Supervised Principal Component Analysis

BACKGROUND: Associations between candidate germline genetic variants and treatment outcome of oxaliplatin, a drug commonly used for patients with colorectal cancer, have been reported but not robustly established. This study aimed to construct polygenic hazard scores (PHSs) as predictive markers for...

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Detalles Bibliográficos
Autores principales: Park, Hanla A., Edelmann, Dominic, Canzian, Federico, Harrison, Tabitha A., Hua, Xinwei, Shi, Qian, Silverman, Allison, Schneider, Martin, Goldberg, Richard M., Alberts, Steven R., Hoffmeister, Michael, Brenner, Hermann, Chan, Andrew T., Peters, Ulrike, Newcomb, Polly A., Chang-Claude, Jenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Null Results in Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627260/
https://www.ncbi.nlm.nih.gov/pubmed/35984985
http://dx.doi.org/10.1158/1055-9965.EPI-22-0320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627260/
https://www.ncbi.nlm.nih.gov/pubmed/35984985
http://dx.doi.org/10.1158/1055-9965.EPI-22-0320

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