PSUN30 Circulating EVs from patients with SDHB mutations increase HIF signaling in hPheo1 cells

Extracellular vesicles (EVs) are nanosized vesicles that carry bioactive cargo from one cell to another and play an important role in intracellular signaling, cell differentiation, and intercellular communication. We investigated and found that packaged cargo of circulating EVs from SDHB mutated phe...

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Autores principales: Ghayee, Hans, Bala, Niharika, Liu, Lauren, Xu, Yiling, Cusi, Kenneth, Pacak, Karel, Alli, Abdel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Diabetes & Glucose Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627271/
http://dx.doi.org/10.1210/jendso/bvac150.847
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author Ghayee, Hans
Bala, Niharika
Liu, Lauren
Xu, Yiling
Cusi, Kenneth
Pacak, Karel
Alli, Abdel
author_facet Ghayee, Hans
Bala, Niharika
Liu, Lauren
Xu, Yiling
Cusi, Kenneth
Pacak, Karel
Alli, Abdel
author_sort Ghayee, Hans
collection PubMed
description Extracellular vesicles (EVs) are nanosized vesicles that carry bioactive cargo from one cell to another and play an important role in intracellular signaling, cell differentiation, and intercellular communication. We investigated and found that packaged cargo of circulating EVs from SDHB mutated pheochromocytoma/paraganglioma patients increase hypoxia-inducible factor (HIF) signaling in a cell model system compared to EVs from control subjects. Keywords: Adrenal Tumors, Endocrine Neoplasia, Neuroendocrinology, succinate dehydrogenase Presentation: Saturday, June 11, 2022 1:00 p.m. - 2:00 p.m.
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spelling pubmed-96272712022-11-03 PSUN30 Circulating EVs from patients with SDHB mutations increase HIF signaling in hPheo1 cells Ghayee, Hans Bala, Niharika Liu, Lauren Xu, Yiling Cusi, Kenneth Pacak, Karel Alli, Abdel J Endocr Soc Diabetes & Glucose Metabolism Extracellular vesicles (EVs) are nanosized vesicles that carry bioactive cargo from one cell to another and play an important role in intracellular signaling, cell differentiation, and intercellular communication. We investigated and found that packaged cargo of circulating EVs from SDHB mutated pheochromocytoma/paraganglioma patients increase hypoxia-inducible factor (HIF) signaling in a cell model system compared to EVs from control subjects. Keywords: Adrenal Tumors, Endocrine Neoplasia, Neuroendocrinology, succinate dehydrogenase Presentation: Saturday, June 11, 2022 1:00 p.m. - 2:00 p.m. Oxford University Press 2022-11-01 /pmc/articles/PMC9627271/ http://dx.doi.org/10.1210/jendso/bvac150.847 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Diabetes & Glucose Metabolism
Ghayee, Hans
Bala, Niharika
Liu, Lauren
Xu, Yiling
Cusi, Kenneth
Pacak, Karel
Alli, Abdel
PSUN30 Circulating EVs from patients with SDHB mutations increase HIF signaling in hPheo1 cells
title PSUN30 Circulating EVs from patients with SDHB mutations increase HIF signaling in hPheo1 cells
title_full PSUN30 Circulating EVs from patients with SDHB mutations increase HIF signaling in hPheo1 cells
title_fullStr PSUN30 Circulating EVs from patients with SDHB mutations increase HIF signaling in hPheo1 cells
title_full_unstemmed PSUN30 Circulating EVs from patients with SDHB mutations increase HIF signaling in hPheo1 cells
title_short PSUN30 Circulating EVs from patients with SDHB mutations increase HIF signaling in hPheo1 cells
title_sort psun30 circulating evs from patients with sdhb mutations increase hif signaling in hpheo1 cells
topic Diabetes & Glucose Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627271/
http://dx.doi.org/10.1210/jendso/bvac150.847
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