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Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-triggered lupus

Autoimmune diseases can be triggered by environmental toxicants such as crystalline silica dust (cSiO(2)). Here, we characterized the dose-dependent immunomodulation and toxicity of the glucocorticoid (GC) prednisone in a preclinical model that emulates onset and progression of cSiO(2)-triggered lup...

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Detalles Bibliográficos
Autores principales:	Heine, Lauren K., Benninghoff, Abby D., Ross, Elizabeth A., Rajasinghe, Lichchavi D., Wagner, James G., Lewandowski, Ryan P., Richardson, Alexa L., Li, Quan-Zhen, Buchweitz, John P., Zyskowski, Justin, Tindle, Ashleigh N., Skedel, Anna E., Chargo, Nicholas J., McCabe, Laura R., Harkema, Jack R., Pestka, James J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627297/ https://www.ncbi.nlm.nih.gov/pubmed/36341330 http://dx.doi.org/10.3389/fimmu.2022.972108

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