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Pitfalls and promises of bile duct alternatives: A narrative review
Biliodigestive anastomosis between the extrahepatic bile duct and the intestine for bile duct disease is a gastrointestinal reconstruction that abolishes duodenal papilla function and frequently causes retrograde cholangitis. This chronic inflammation can cause liver dysfunction, liver abscess, and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627420/ https://www.ncbi.nlm.nih.gov/pubmed/36338889 http://dx.doi.org/10.3748/wjg.v28.i39.5707 |
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author | Miyazawa, Mitsuo Aikawa, Masayasu Takashima, Junpei Kobayashi, Hirotoshi Ohnishi, Shunsuke Ikada, Yoshito |
author_facet | Miyazawa, Mitsuo Aikawa, Masayasu Takashima, Junpei Kobayashi, Hirotoshi Ohnishi, Shunsuke Ikada, Yoshito |
author_sort | Miyazawa, Mitsuo |
collection | PubMed |
description | Biliodigestive anastomosis between the extrahepatic bile duct and the intestine for bile duct disease is a gastrointestinal reconstruction that abolishes duodenal papilla function and frequently causes retrograde cholangitis. This chronic inflammation can cause liver dysfunction, liver abscess, and even bile duct cancer. Although research has been conducted for over 100 years to directly repair bile duct defects with alternatives, no bile duct substitute (BDS) has been developed. This narrative review confirms our understanding of why bile duct alternatives have not been developed and explains the clinical applicability of BDSs in the near future. We searched the PubMed electronic database to identify studies conducted to develop BDSs until December 2021 and identified studies in English. Two independent reviewers reviewed studies on large animals with 8 or more cases. Four types of BDSs prevail: Autologous tissue, non-bioabsorbable material, bioabsorbable material, and others (decellularized tissue, 3D-printed structures, etc.). In most studies, BDSs failed due to obstruction of the lumen or stenosis of the anastomosis with the native bile duct. BDS has not been developed primarily because control of bile duct wound healing and regeneration has not been elucidated. A BDS expected to be clinically applied in the near future incorporates a bioabsorbable material that allows for regeneration of the bile duct outside the BDS. |
format | Online Article Text |
id | pubmed-9627420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-96274202022-11-03 Pitfalls and promises of bile duct alternatives: A narrative review Miyazawa, Mitsuo Aikawa, Masayasu Takashima, Junpei Kobayashi, Hirotoshi Ohnishi, Shunsuke Ikada, Yoshito World J Gastroenterol Minireviews Biliodigestive anastomosis between the extrahepatic bile duct and the intestine for bile duct disease is a gastrointestinal reconstruction that abolishes duodenal papilla function and frequently causes retrograde cholangitis. This chronic inflammation can cause liver dysfunction, liver abscess, and even bile duct cancer. Although research has been conducted for over 100 years to directly repair bile duct defects with alternatives, no bile duct substitute (BDS) has been developed. This narrative review confirms our understanding of why bile duct alternatives have not been developed and explains the clinical applicability of BDSs in the near future. We searched the PubMed electronic database to identify studies conducted to develop BDSs until December 2021 and identified studies in English. Two independent reviewers reviewed studies on large animals with 8 or more cases. Four types of BDSs prevail: Autologous tissue, non-bioabsorbable material, bioabsorbable material, and others (decellularized tissue, 3D-printed structures, etc.). In most studies, BDSs failed due to obstruction of the lumen or stenosis of the anastomosis with the native bile duct. BDS has not been developed primarily because control of bile duct wound healing and regeneration has not been elucidated. A BDS expected to be clinically applied in the near future incorporates a bioabsorbable material that allows for regeneration of the bile duct outside the BDS. Baishideng Publishing Group Inc 2022-10-21 2022-10-21 /pmc/articles/PMC9627420/ /pubmed/36338889 http://dx.doi.org/10.3748/wjg.v28.i39.5707 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Miyazawa, Mitsuo Aikawa, Masayasu Takashima, Junpei Kobayashi, Hirotoshi Ohnishi, Shunsuke Ikada, Yoshito Pitfalls and promises of bile duct alternatives: A narrative review |
title | Pitfalls and promises of bile duct alternatives: A narrative review |
title_full | Pitfalls and promises of bile duct alternatives: A narrative review |
title_fullStr | Pitfalls and promises of bile duct alternatives: A narrative review |
title_full_unstemmed | Pitfalls and promises of bile duct alternatives: A narrative review |
title_short | Pitfalls and promises of bile duct alternatives: A narrative review |
title_sort | pitfalls and promises of bile duct alternatives: a narrative review |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627420/ https://www.ncbi.nlm.nih.gov/pubmed/36338889 http://dx.doi.org/10.3748/wjg.v28.i39.5707 |
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