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Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider
Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms, including gallbladder cancer. In this regard, data derived from clinical and experimental studies have demonstrated that the receptor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627425/ https://www.ncbi.nlm.nih.gov/pubmed/36338887 http://dx.doi.org/10.3748/wjg.v28.i39.5679 |
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author | Rojas, Armando Lindner, Cristian Schneider, Iván Gonzàlez, Ileana Morales, Miguel Angel |
author_facet | Rojas, Armando Lindner, Cristian Schneider, Iván Gonzàlez, Ileana Morales, Miguel Angel |
author_sort | Rojas, Armando |
collection | PubMed |
description | Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms, including gallbladder cancer. In this regard, data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products (RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu, thus supporting tumor growth and development. AGEs are formed in biological systems or foods, and food-derived AGEs, also known as dietary AGEs are known to contribute to the systemic pool of AGEs. Once they bind to RAGE, the activation of multiple and crucial signaling pathways are triggered, thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and migration. In the present review, we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer, and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts. |
format | Online Article Text |
id | pubmed-9627425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-96274252022-11-03 Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider Rojas, Armando Lindner, Cristian Schneider, Iván Gonzàlez, Ileana Morales, Miguel Angel World J Gastroenterol Review Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms, including gallbladder cancer. In this regard, data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products (RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu, thus supporting tumor growth and development. AGEs are formed in biological systems or foods, and food-derived AGEs, also known as dietary AGEs are known to contribute to the systemic pool of AGEs. Once they bind to RAGE, the activation of multiple and crucial signaling pathways are triggered, thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and migration. In the present review, we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer, and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts. Baishideng Publishing Group Inc 2022-10-21 2022-10-21 /pmc/articles/PMC9627425/ /pubmed/36338887 http://dx.doi.org/10.3748/wjg.v28.i39.5679 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Rojas, Armando Lindner, Cristian Schneider, Iván Gonzàlez, Ileana Morales, Miguel Angel Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider |
title | Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider |
title_full | Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider |
title_fullStr | Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider |
title_full_unstemmed | Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider |
title_short | Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider |
title_sort | receptor of advanced glycation end-products axis and gallbladder cancer: a forgotten connection that we should reconsider |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627425/ https://www.ncbi.nlm.nih.gov/pubmed/36338887 http://dx.doi.org/10.3748/wjg.v28.i39.5679 |
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