Cargando…

Autoantibodies - enemies, and/or potential allies?

Autoantibodies are well known as potentially highly harmful antibodies which attack the host via binding to self-antigens, thus causing severe associated diseases and symptoms (e.g. autoimmune diseases). However, detection of autoantibodies to a range of disease-associated antigens has enabled their...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Hui, Murphy, Caroline, Loscher, Christine E., O’Kennedy, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627499/
https://www.ncbi.nlm.nih.gov/pubmed/36341384
http://dx.doi.org/10.3389/fimmu.2022.953726
_version_ 1784822984090845184
author Ma, Hui
Murphy, Caroline
Loscher, Christine E.
O’Kennedy, Richard
author_facet Ma, Hui
Murphy, Caroline
Loscher, Christine E.
O’Kennedy, Richard
author_sort Ma, Hui
collection PubMed
description Autoantibodies are well known as potentially highly harmful antibodies which attack the host via binding to self-antigens, thus causing severe associated diseases and symptoms (e.g. autoimmune diseases). However, detection of autoantibodies to a range of disease-associated antigens has enabled their successful usage as important tools in disease diagnosis, prognosis and treatment. There are several advantages of using such autoantibodies. These include the capacity to measure their presence very early in disease development, their stability, which is often much better than their related antigen, and the capacity to use an array of such autoantibodies for enhanced diagnostics and to better predict prognosis. They may also possess capacity for utilization in therapy, in vivo. In this review both the positive and negative aspects of autoantibodies are critically assessed, including their role in autoimmune diseases, cancers and the global pandemic caused by COVID-19. Important issues related to their detection are also highlighted.
format Online
Article
Text
id pubmed-9627499
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96274992022-11-03 Autoantibodies - enemies, and/or potential allies? Ma, Hui Murphy, Caroline Loscher, Christine E. O’Kennedy, Richard Front Immunol Immunology Autoantibodies are well known as potentially highly harmful antibodies which attack the host via binding to self-antigens, thus causing severe associated diseases and symptoms (e.g. autoimmune diseases). However, detection of autoantibodies to a range of disease-associated antigens has enabled their successful usage as important tools in disease diagnosis, prognosis and treatment. There are several advantages of using such autoantibodies. These include the capacity to measure their presence very early in disease development, their stability, which is often much better than their related antigen, and the capacity to use an array of such autoantibodies for enhanced diagnostics and to better predict prognosis. They may also possess capacity for utilization in therapy, in vivo. In this review both the positive and negative aspects of autoantibodies are critically assessed, including their role in autoimmune diseases, cancers and the global pandemic caused by COVID-19. Important issues related to their detection are also highlighted. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9627499/ /pubmed/36341384 http://dx.doi.org/10.3389/fimmu.2022.953726 Text en Copyright © 2022 Ma, Murphy, Loscher and O’Kennedy https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ma, Hui
Murphy, Caroline
Loscher, Christine E.
O’Kennedy, Richard
Autoantibodies - enemies, and/or potential allies?
title Autoantibodies - enemies, and/or potential allies?
title_full Autoantibodies - enemies, and/or potential allies?
title_fullStr Autoantibodies - enemies, and/or potential allies?
title_full_unstemmed Autoantibodies - enemies, and/or potential allies?
title_short Autoantibodies - enemies, and/or potential allies?
title_sort autoantibodies - enemies, and/or potential allies?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627499/
https://www.ncbi.nlm.nih.gov/pubmed/36341384
http://dx.doi.org/10.3389/fimmu.2022.953726
work_keys_str_mv AT mahui autoantibodiesenemiesandorpotentialallies
AT murphycaroline autoantibodiesenemiesandorpotentialallies
AT loscherchristinee autoantibodiesenemiesandorpotentialallies
AT okennedyrichard autoantibodiesenemiesandorpotentialallies