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Autoantibodies - enemies, and/or potential allies?
Autoantibodies are well known as potentially highly harmful antibodies which attack the host via binding to self-antigens, thus causing severe associated diseases and symptoms (e.g. autoimmune diseases). However, detection of autoantibodies to a range of disease-associated antigens has enabled their...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627499/ https://www.ncbi.nlm.nih.gov/pubmed/36341384 http://dx.doi.org/10.3389/fimmu.2022.953726 |
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author | Ma, Hui Murphy, Caroline Loscher, Christine E. O’Kennedy, Richard |
author_facet | Ma, Hui Murphy, Caroline Loscher, Christine E. O’Kennedy, Richard |
author_sort | Ma, Hui |
collection | PubMed |
description | Autoantibodies are well known as potentially highly harmful antibodies which attack the host via binding to self-antigens, thus causing severe associated diseases and symptoms (e.g. autoimmune diseases). However, detection of autoantibodies to a range of disease-associated antigens has enabled their successful usage as important tools in disease diagnosis, prognosis and treatment. There are several advantages of using such autoantibodies. These include the capacity to measure their presence very early in disease development, their stability, which is often much better than their related antigen, and the capacity to use an array of such autoantibodies for enhanced diagnostics and to better predict prognosis. They may also possess capacity for utilization in therapy, in vivo. In this review both the positive and negative aspects of autoantibodies are critically assessed, including their role in autoimmune diseases, cancers and the global pandemic caused by COVID-19. Important issues related to their detection are also highlighted. |
format | Online Article Text |
id | pubmed-9627499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96274992022-11-03 Autoantibodies - enemies, and/or potential allies? Ma, Hui Murphy, Caroline Loscher, Christine E. O’Kennedy, Richard Front Immunol Immunology Autoantibodies are well known as potentially highly harmful antibodies which attack the host via binding to self-antigens, thus causing severe associated diseases and symptoms (e.g. autoimmune diseases). However, detection of autoantibodies to a range of disease-associated antigens has enabled their successful usage as important tools in disease diagnosis, prognosis and treatment. There are several advantages of using such autoantibodies. These include the capacity to measure their presence very early in disease development, their stability, which is often much better than their related antigen, and the capacity to use an array of such autoantibodies for enhanced diagnostics and to better predict prognosis. They may also possess capacity for utilization in therapy, in vivo. In this review both the positive and negative aspects of autoantibodies are critically assessed, including their role in autoimmune diseases, cancers and the global pandemic caused by COVID-19. Important issues related to their detection are also highlighted. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9627499/ /pubmed/36341384 http://dx.doi.org/10.3389/fimmu.2022.953726 Text en Copyright © 2022 Ma, Murphy, Loscher and O’Kennedy https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ma, Hui Murphy, Caroline Loscher, Christine E. O’Kennedy, Richard Autoantibodies - enemies, and/or potential allies? |
title | Autoantibodies - enemies, and/or potential allies? |
title_full | Autoantibodies - enemies, and/or potential allies? |
title_fullStr | Autoantibodies - enemies, and/or potential allies? |
title_full_unstemmed | Autoantibodies - enemies, and/or potential allies? |
title_short | Autoantibodies - enemies, and/or potential allies? |
title_sort | autoantibodies - enemies, and/or potential allies? |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627499/ https://www.ncbi.nlm.nih.gov/pubmed/36341384 http://dx.doi.org/10.3389/fimmu.2022.953726 |
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