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Temperature-dependent structural plasticity of hippocampal synapses

The function of the central nervous system (CNS) is strongly affected by temperature. However, the underlying processes remain poorly understood. Here, we show that hypothermia and hyperthermia trigger bidirectional re-organization of presynaptic architecture in hippocampal neurons, resulting in syn...

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Autores principales: Feng, Zhendong, Saha, Lopamudra, Dritsa, Clio, Wan, Qi, Glebov, Oleg O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627613/
https://www.ncbi.nlm.nih.gov/pubmed/36339823
http://dx.doi.org/10.3389/fncel.2022.1009970
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author Feng, Zhendong
Saha, Lopamudra
Dritsa, Clio
Wan, Qi
Glebov, Oleg O.
author_facet Feng, Zhendong
Saha, Lopamudra
Dritsa, Clio
Wan, Qi
Glebov, Oleg O.
author_sort Feng, Zhendong
collection PubMed
description The function of the central nervous system (CNS) is strongly affected by temperature. However, the underlying processes remain poorly understood. Here, we show that hypothermia and hyperthermia trigger bidirectional re-organization of presynaptic architecture in hippocampal neurons, resulting in synaptic strengthening, and weakening, respectively. Furthermore, hypothermia remodels inhibitory postsynaptic scaffold into enlarged, sparse synapses enriched in GABAA receptors. This process does not require protein translation, and instead is regulated by actin dynamics. Induction of hypothermia in vivo enhances inhibitory synapses in the hippocampus, but not in the cortex. This is confirmed by the proteomic analysis of cortical synapses, which reveals few temperature-dependent changes in synaptic content. Our results reveal a region-specific form of environmental synaptic plasticity with a mechanism distinct from the classic temperature shock response, which may underlie functional response of CNS to temperature.
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spelling pubmed-96276132022-11-03 Temperature-dependent structural plasticity of hippocampal synapses Feng, Zhendong Saha, Lopamudra Dritsa, Clio Wan, Qi Glebov, Oleg O. Front Cell Neurosci Neuroscience The function of the central nervous system (CNS) is strongly affected by temperature. However, the underlying processes remain poorly understood. Here, we show that hypothermia and hyperthermia trigger bidirectional re-organization of presynaptic architecture in hippocampal neurons, resulting in synaptic strengthening, and weakening, respectively. Furthermore, hypothermia remodels inhibitory postsynaptic scaffold into enlarged, sparse synapses enriched in GABAA receptors. This process does not require protein translation, and instead is regulated by actin dynamics. Induction of hypothermia in vivo enhances inhibitory synapses in the hippocampus, but not in the cortex. This is confirmed by the proteomic analysis of cortical synapses, which reveals few temperature-dependent changes in synaptic content. Our results reveal a region-specific form of environmental synaptic plasticity with a mechanism distinct from the classic temperature shock response, which may underlie functional response of CNS to temperature. Frontiers Media S.A. 2022-10-19 /pmc/articles/PMC9627613/ /pubmed/36339823 http://dx.doi.org/10.3389/fncel.2022.1009970 Text en Copyright © 2022 Feng, Saha, Dritsa, Wan and Glebov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Feng, Zhendong
Saha, Lopamudra
Dritsa, Clio
Wan, Qi
Glebov, Oleg O.
Temperature-dependent structural plasticity of hippocampal synapses
title Temperature-dependent structural plasticity of hippocampal synapses
title_full Temperature-dependent structural plasticity of hippocampal synapses
title_fullStr Temperature-dependent structural plasticity of hippocampal synapses
title_full_unstemmed Temperature-dependent structural plasticity of hippocampal synapses
title_short Temperature-dependent structural plasticity of hippocampal synapses
title_sort temperature-dependent structural plasticity of hippocampal synapses
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627613/
https://www.ncbi.nlm.nih.gov/pubmed/36339823
http://dx.doi.org/10.3389/fncel.2022.1009970
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