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OR11-1 Thyroglobulin Structural Requirements in Protein Trafficking for Thyroid Hormonogenesis

In vertebrates, thyroglobulin (Tg) is secreted into the lumen of thyroid follicles to enable its iodination for the synthesis of thyroid hormone — defective Tg secretion causes hypothyroidism. A defining step in Tg secretion is export from the endoplasmic reticulum (ER), but Tg structural features n...

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Detalles Bibliográficos
Autores principales:	Arvan, Peter, Clarke, Oliver, Kim, Kookjoo, Citterio, Cintia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Thyroid
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627654/ http://dx.doi.org/10.1210/jendso/bvac150.1651

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