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Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction with APP

Alzheimer's disease (AD) pathogenesis has been linked to the accumulation of longer, aggregation‐prone amyloid β (Aβ) peptides in the brain. Γ‐secretases generate Aβ peptides from the amyloid precursor protein (APP). Γ‐secretase modulators (GSMs) promote the generation of shorter, less‐amyloido...

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Detalles Bibliográficos
Autores principales:	Petit, Dieter, Hitzenberger, Manuel, Koch, Matthias, Lismont, Sam, Zoltowska, Katarzyna Marta, Enzlein, Thomas, Hopf, Carsten, Zacharias, Martin, Chávez‐Gutiérrez, Lucía
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627667/ https://www.ncbi.nlm.nih.gov/pubmed/36121025 http://dx.doi.org/10.15252/embj.2022111084

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