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Targeting the DNA damage response and repair in cancer through nucleotide metabolism

The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of DNA are dependent upon the supply of deoxynucleoside triphosphate (dNTP) building blocks, which are produced and maintained by nucleotide metaboli...

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Detalles Bibliográficos
Autores principales: Helleday, Thomas, Rudd, Sean G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627788/
https://www.ncbi.nlm.nih.gov/pubmed/35583750
http://dx.doi.org/10.1002/1878-0261.13227

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