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PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion
MATERIALS AND METHODS: The study enrolled 2 men aged 58 years (history of acute cerebral circulation disorder at 47 and 57 years) and 64 years (history of acute myocardial infarction at 62 years), who complained of shortness of breath, daytime sleepiness, decreased libido, weakened erections, increa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627912/ http://dx.doi.org/10.1210/jendso/bvac150.1504 |
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author | Mostovaya, Maria Kalinchenko, Svetlana Vorslov, Leonid |
author_facet | Mostovaya, Maria Kalinchenko, Svetlana Vorslov, Leonid |
author_sort | Mostovaya, Maria |
collection | PubMed |
description | MATERIALS AND METHODS: The study enrolled 2 men aged 58 years (history of acute cerebral circulation disorder at 47 and 57 years) and 64 years (history of acute myocardial infarction at 62 years), who complained of shortness of breath, daytime sleepiness, decreased libido, weakened erections, increased blood pressure. Both patients had been taking atorvastatin 10 mg for more than three months. We used high-performance liquid chromatography (HPLC) to determine steroid hormones in saliva: Agilent 1200 chromatograph, AB Sciex 3200 MD mass spectrometer (Sciex, USA). Saliva was collected in a Salivette container. A significant decrease in pregnenolone levels of 440.0 pg/ml and 300 pg/ml, respectively, was detected in the saliva analyses). The norm for pregnenolone was 575-665 pg/ml. CONCLUSION: Statins lead to decreased pregnenolone secretion, most likely due to inhibition of HMG-CoA reductase, a key enzyme that converts 3-hydroxy-3-methyl glutaryl-CoA to mevalonate, a cholesterol precursor. The decrease in cholesterol synthesis leads to a decrease in pregnenolone and a decrease in steroid hormone secretion, both in the adrenal glands and gonads, which clinically manifests as hypogonadism and adrenal fatigue. All patients taking statins should have their salivary steroid profile evaluated. If statins cannot be withdrawn, hormone replacement therapy with sex hormones is necessary. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m. |
format | Online Article Text |
id | pubmed-9627912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-96279122022-11-04 PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion Mostovaya, Maria Kalinchenko, Svetlana Vorslov, Leonid J Endocr Soc Steroid Hormones and Receptors MATERIALS AND METHODS: The study enrolled 2 men aged 58 years (history of acute cerebral circulation disorder at 47 and 57 years) and 64 years (history of acute myocardial infarction at 62 years), who complained of shortness of breath, daytime sleepiness, decreased libido, weakened erections, increased blood pressure. Both patients had been taking atorvastatin 10 mg for more than three months. We used high-performance liquid chromatography (HPLC) to determine steroid hormones in saliva: Agilent 1200 chromatograph, AB Sciex 3200 MD mass spectrometer (Sciex, USA). Saliva was collected in a Salivette container. A significant decrease in pregnenolone levels of 440.0 pg/ml and 300 pg/ml, respectively, was detected in the saliva analyses). The norm for pregnenolone was 575-665 pg/ml. CONCLUSION: Statins lead to decreased pregnenolone secretion, most likely due to inhibition of HMG-CoA reductase, a key enzyme that converts 3-hydroxy-3-methyl glutaryl-CoA to mevalonate, a cholesterol precursor. The decrease in cholesterol synthesis leads to a decrease in pregnenolone and a decrease in steroid hormone secretion, both in the adrenal glands and gonads, which clinically manifests as hypogonadism and adrenal fatigue. All patients taking statins should have their salivary steroid profile evaluated. If statins cannot be withdrawn, hormone replacement therapy with sex hormones is necessary. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m. Oxford University Press 2022-11-01 /pmc/articles/PMC9627912/ http://dx.doi.org/10.1210/jendso/bvac150.1504 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Steroid Hormones and Receptors Mostovaya, Maria Kalinchenko, Svetlana Vorslov, Leonid PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion |
title | PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion |
title_full | PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion |
title_fullStr | PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion |
title_full_unstemmed | PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion |
title_short | PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion |
title_sort | psun66 statin intake as a cause of decreased steroid hormone secretion |
topic | Steroid Hormones and Receptors |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627912/ http://dx.doi.org/10.1210/jendso/bvac150.1504 |
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