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PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion

MATERIALS AND METHODS: The study enrolled 2 men aged 58 years (history of acute cerebral circulation disorder at 47 and 57 years) and 64 years (history of acute myocardial infarction at 62 years), who complained of shortness of breath, daytime sleepiness, decreased libido, weakened erections, increa...

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Autores principales: Mostovaya, Maria, Kalinchenko, Svetlana, Vorslov, Leonid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627912/
http://dx.doi.org/10.1210/jendso/bvac150.1504
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author Mostovaya, Maria
Kalinchenko, Svetlana
Vorslov, Leonid
author_facet Mostovaya, Maria
Kalinchenko, Svetlana
Vorslov, Leonid
author_sort Mostovaya, Maria
collection PubMed
description MATERIALS AND METHODS: The study enrolled 2 men aged 58 years (history of acute cerebral circulation disorder at 47 and 57 years) and 64 years (history of acute myocardial infarction at 62 years), who complained of shortness of breath, daytime sleepiness, decreased libido, weakened erections, increased blood pressure. Both patients had been taking atorvastatin 10 mg for more than three months. We used high-performance liquid chromatography (HPLC) to determine steroid hormones in saliva: Agilent 1200 chromatograph, AB Sciex 3200 MD mass spectrometer (Sciex, USA). Saliva was collected in a Salivette container. A significant decrease in pregnenolone levels of 440.0 pg/ml and 300 pg/ml, respectively, was detected in the saliva analyses). The norm for pregnenolone was 575-665 pg/ml. CONCLUSION: Statins lead to decreased pregnenolone secretion, most likely due to inhibition of HMG-CoA reductase, a key enzyme that converts 3-hydroxy-3-methyl glutaryl-CoA to mevalonate, a cholesterol precursor. The decrease in cholesterol synthesis leads to a decrease in pregnenolone and a decrease in steroid hormone secretion, both in the adrenal glands and gonads, which clinically manifests as hypogonadism and adrenal fatigue. All patients taking statins should have their salivary steroid profile evaluated. If statins cannot be withdrawn, hormone replacement therapy with sex hormones is necessary. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.
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spelling pubmed-96279122022-11-04 PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion Mostovaya, Maria Kalinchenko, Svetlana Vorslov, Leonid J Endocr Soc Steroid Hormones and Receptors MATERIALS AND METHODS: The study enrolled 2 men aged 58 years (history of acute cerebral circulation disorder at 47 and 57 years) and 64 years (history of acute myocardial infarction at 62 years), who complained of shortness of breath, daytime sleepiness, decreased libido, weakened erections, increased blood pressure. Both patients had been taking atorvastatin 10 mg for more than three months. We used high-performance liquid chromatography (HPLC) to determine steroid hormones in saliva: Agilent 1200 chromatograph, AB Sciex 3200 MD mass spectrometer (Sciex, USA). Saliva was collected in a Salivette container. A significant decrease in pregnenolone levels of 440.0 pg/ml and 300 pg/ml, respectively, was detected in the saliva analyses). The norm for pregnenolone was 575-665 pg/ml. CONCLUSION: Statins lead to decreased pregnenolone secretion, most likely due to inhibition of HMG-CoA reductase, a key enzyme that converts 3-hydroxy-3-methyl glutaryl-CoA to mevalonate, a cholesterol precursor. The decrease in cholesterol synthesis leads to a decrease in pregnenolone and a decrease in steroid hormone secretion, both in the adrenal glands and gonads, which clinically manifests as hypogonadism and adrenal fatigue. All patients taking statins should have their salivary steroid profile evaluated. If statins cannot be withdrawn, hormone replacement therapy with sex hormones is necessary. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m. Oxford University Press 2022-11-01 /pmc/articles/PMC9627912/ http://dx.doi.org/10.1210/jendso/bvac150.1504 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Steroid Hormones and Receptors
Mostovaya, Maria
Kalinchenko, Svetlana
Vorslov, Leonid
PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion
title PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion
title_full PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion
title_fullStr PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion
title_full_unstemmed PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion
title_short PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion
title_sort psun66 statin intake as a cause of decreased steroid hormone secretion
topic Steroid Hormones and Receptors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627912/
http://dx.doi.org/10.1210/jendso/bvac150.1504
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