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Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management

BACKGROUND: Synchronous multiple primary lung cancers associated with small non-dominant nodules are commonly encountered. However, the incidence, follow-up, and treatment of small non-dominant tumors have been but little studied. We explored the prevalence and management of small non-dominant tumor...

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Autores principales: Cheng, Hua, Li, Wen-hao, Li, Xiao-jian, Zhong, Hong-cheng, Wang, Xiao-jin, Lin, Yu-jing, Liu, Xue-guo, Wu, Xiang-wen, Cao, Qing-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628062/
https://www.ncbi.nlm.nih.gov/pubmed/36320014
http://dx.doi.org/10.1186/s13019-022-02022-2
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author Cheng, Hua
Li, Wen-hao
Li, Xiao-jian
Zhong, Hong-cheng
Wang, Xiao-jin
Lin, Yu-jing
Liu, Xue-guo
Wu, Xiang-wen
Cao, Qing-dong
author_facet Cheng, Hua
Li, Wen-hao
Li, Xiao-jian
Zhong, Hong-cheng
Wang, Xiao-jin
Lin, Yu-jing
Liu, Xue-guo
Wu, Xiang-wen
Cao, Qing-dong
author_sort Cheng, Hua
collection PubMed
description BACKGROUND: Synchronous multiple primary lung cancers associated with small non-dominant nodules are commonly encountered. However, the incidence, follow-up, and treatment of small non-dominant tumors have been but little studied. We explored the prevalence and management of small non-dominant tumors and factors associated with interval growth. METHODS: This observational, consecutive, retrospective single-center study enrolled patients diagnosed with synchronous multiple primary lung cancers and small non-dominant tumors (≤ 6 mm in diameter) who underwent resection of the dominant tumor. The incidence, follow-up, and management of small non-dominant tumors and predictors of nodule growth were analyzed. RESULTS: There were 88 patients (12% of all lung cancer patients) with pathological diagnoses of synchronous multiple primary lung cancers. A total of 131 (18%) patients were clinically diagnosed with at least one small (≤ 6 mm in diameter) multiple primary lung cancer non-dominant tumor. 94 patients with 125 small-nodule non-dominant tumors clinically diagnosed as multiple primary lung cancers were followed-up for at least 6 months. A total of 29 (29/125, 23.2%) evidenced small pulmonary nodules (≤ 6 mm in diameter) that exhibited interval growth on follow-up computed tomography (CT). On multivariate analysis, a part-solid nodule (compared to a pGGN) (OR 1.23; 95% CI 1.08–1.40) or a solid nodule (compared to a pGGN) (OR 3.50; 95% CI 1.94–6.30) predicted small nodule interval growth. CONCLUSION: We found a relatively high incidence of multiple primary lung cancers with small non-dominant tumors exhibiting interval growth on follow-up CT, suggesting that resection of non-dominant tumors at the time of dominant tumor resection, especially when the nodules are part-solid or solid, is the optimal treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13019-022-02022-2.
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spelling pubmed-96280622022-11-03 Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management Cheng, Hua Li, Wen-hao Li, Xiao-jian Zhong, Hong-cheng Wang, Xiao-jin Lin, Yu-jing Liu, Xue-guo Wu, Xiang-wen Cao, Qing-dong J Cardiothorac Surg Research Article BACKGROUND: Synchronous multiple primary lung cancers associated with small non-dominant nodules are commonly encountered. However, the incidence, follow-up, and treatment of small non-dominant tumors have been but little studied. We explored the prevalence and management of small non-dominant tumors and factors associated with interval growth. METHODS: This observational, consecutive, retrospective single-center study enrolled patients diagnosed with synchronous multiple primary lung cancers and small non-dominant tumors (≤ 6 mm in diameter) who underwent resection of the dominant tumor. The incidence, follow-up, and management of small non-dominant tumors and predictors of nodule growth were analyzed. RESULTS: There were 88 patients (12% of all lung cancer patients) with pathological diagnoses of synchronous multiple primary lung cancers. A total of 131 (18%) patients were clinically diagnosed with at least one small (≤ 6 mm in diameter) multiple primary lung cancer non-dominant tumor. 94 patients with 125 small-nodule non-dominant tumors clinically diagnosed as multiple primary lung cancers were followed-up for at least 6 months. A total of 29 (29/125, 23.2%) evidenced small pulmonary nodules (≤ 6 mm in diameter) that exhibited interval growth on follow-up computed tomography (CT). On multivariate analysis, a part-solid nodule (compared to a pGGN) (OR 1.23; 95% CI 1.08–1.40) or a solid nodule (compared to a pGGN) (OR 3.50; 95% CI 1.94–6.30) predicted small nodule interval growth. CONCLUSION: We found a relatively high incidence of multiple primary lung cancers with small non-dominant tumors exhibiting interval growth on follow-up CT, suggesting that resection of non-dominant tumors at the time of dominant tumor resection, especially when the nodules are part-solid or solid, is the optimal treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13019-022-02022-2. BioMed Central 2022-11-01 /pmc/articles/PMC9628062/ /pubmed/36320014 http://dx.doi.org/10.1186/s13019-022-02022-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Cheng, Hua
Li, Wen-hao
Li, Xiao-jian
Zhong, Hong-cheng
Wang, Xiao-jin
Lin, Yu-jing
Liu, Xue-guo
Wu, Xiang-wen
Cao, Qing-dong
Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management
title Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management
title_full Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management
title_fullStr Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management
title_full_unstemmed Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management
title_short Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management
title_sort small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628062/
https://www.ncbi.nlm.nih.gov/pubmed/36320014
http://dx.doi.org/10.1186/s13019-022-02022-2
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