Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients

BACKGROUND: Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal genetic...

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Detalles Bibliográficos
Autores principales: Li, Yan, Chen, Lili, Lv, Jinxing, Chen, Xiaobin, Zeng, Bangwei, Chen, Minyan, Guo, Wenhui, Lin, Yuxiang, Yu, Liuwen, Hou, Jialin, Li, Jing, Zhou, Peng, Zhang, Wenzhe, Li, Shengmei, Jin, Xuan, Cai, Weifeng, Zhang, Kun, Huang, Yeyuan, Wang, Chuan, Fu, Fangmeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628090/
https://www.ncbi.nlm.nih.gov/pubmed/36324133
http://dx.doi.org/10.1186/s12885-022-10160-y

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