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Nutritional deficiency induces nucleus pulposus cell apoptosis via the ATF4-PKM2-AKT signal axis

BACKGROUND: The intervertebral disc is the largest avascular tissue in the human body. The nucleus pulposus (NP) consumes glucose and oxygen to generate energy to maintain cellular metabolism via nutrients that diffuse from the cartilage endplate. The microenvironment in the intervertebral disc beco...

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Detalles Bibliográficos
Autores principales:	Zhou, Ningfeng, Shen, Bin, Bai, Chong, Ma, Liang, Wang, Shanjin, Wu, Desheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628105/ https://www.ncbi.nlm.nih.gov/pubmed/36324122 http://dx.doi.org/10.1186/s12891-022-05853-1

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