Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark of cancer, Warburg effect promotes cancer metastasis and remodels the tumor microenvironment, including promoting...

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Autores principales: Zhong, Xinyang, He, Xuefeng, Wang, Yaxian, Hu, Zijuan, Huang, Huixia, Zhao, Senlin, Wei, Ping, Li, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628128/
https://www.ncbi.nlm.nih.gov/pubmed/36319992
http://dx.doi.org/10.1186/s13045-022-01358-5
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author Zhong, Xinyang
He, Xuefeng
Wang, Yaxian
Hu, Zijuan
Huang, Huixia
Zhao, Senlin
Wei, Ping
Li, Dawei
author_facet Zhong, Xinyang
He, Xuefeng
Wang, Yaxian
Hu, Zijuan
Huang, Huixia
Zhao, Senlin
Wei, Ping
Li, Dawei
author_sort Zhong, Xinyang
collection PubMed
description Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark of cancer, Warburg effect promotes cancer metastasis and remodels the tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation and drug resistance. Targeting Warburg metabolism would be a promising method for the treatment of CRC. In this review, we summarize information about the roles of Warburg effect in tumor microenvironment to elucidate the mechanisms governing Warburg effect in CRC and to identify novel targets for therapy.
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spelling pubmed-96281282022-11-03 Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications Zhong, Xinyang He, Xuefeng Wang, Yaxian Hu, Zijuan Huang, Huixia Zhao, Senlin Wei, Ping Li, Dawei J Hematol Oncol Review Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark of cancer, Warburg effect promotes cancer metastasis and remodels the tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation and drug resistance. Targeting Warburg metabolism would be a promising method for the treatment of CRC. In this review, we summarize information about the roles of Warburg effect in tumor microenvironment to elucidate the mechanisms governing Warburg effect in CRC and to identify novel targets for therapy. BioMed Central 2022-11-01 /pmc/articles/PMC9628128/ /pubmed/36319992 http://dx.doi.org/10.1186/s13045-022-01358-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhong, Xinyang
He, Xuefeng
Wang, Yaxian
Hu, Zijuan
Huang, Huixia
Zhao, Senlin
Wei, Ping
Li, Dawei
Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
title Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
title_full Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
title_fullStr Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
title_full_unstemmed Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
title_short Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
title_sort warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628128/
https://www.ncbi.nlm.nih.gov/pubmed/36319992
http://dx.doi.org/10.1186/s13045-022-01358-5
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