De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019

The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the e...

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Detalles Bibliográficos
Autores principales: Jeannet, Robin, Descazeaud, Alexandra, Daix, Thomas, Pauthier, Hélène, Pascal, Virginie, Hantz, Sébastien, Cam, Sophie Le, Francois, Bruno, Feuillard, Jean, Lafarge, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628129/
https://www.ncbi.nlm.nih.gov/pubmed/36403401
http://dx.doi.org/10.1016/j.jiph.2022.10.025
Descripción
Sumario:The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the emergence of a de novo natural alloantibody which targeted the M antigen from the MNS blood group on red blood cells (RBC) without evidence of any cross-reaction with SARS-CoV-2 antigens. This IgM lambda alloantibody was unmutated and unswitched. Here, we describe for the first time the emergence of a bystander de novo natural alloantibody against RBCs in a severe COVID-19 patient, highlighting the extra-follicular humoral response reported in these cases.

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