De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019

The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the e...

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Autores principales: Jeannet, Robin, Descazeaud, Alexandra, Daix, Thomas, Pauthier, Hélène, Pascal, Virginie, Hantz, Sébastien, Cam, Sophie Le, Francois, Bruno, Feuillard, Jean, Lafarge, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628129/
https://www.ncbi.nlm.nih.gov/pubmed/36403401
http://dx.doi.org/10.1016/j.jiph.2022.10.025
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author Jeannet, Robin
Descazeaud, Alexandra
Daix, Thomas
Pauthier, Hélène
Pascal, Virginie
Hantz, Sébastien
Cam, Sophie Le
Francois, Bruno
Feuillard, Jean
Lafarge, Xavier
author_facet Jeannet, Robin
Descazeaud, Alexandra
Daix, Thomas
Pauthier, Hélène
Pascal, Virginie
Hantz, Sébastien
Cam, Sophie Le
Francois, Bruno
Feuillard, Jean
Lafarge, Xavier
author_sort Jeannet, Robin
collection PubMed
description The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the emergence of a de novo natural alloantibody which targeted the M antigen from the MNS blood group on red blood cells (RBC) without evidence of any cross-reaction with SARS-CoV-2 antigens. This IgM lambda alloantibody was unmutated and unswitched. Here, we describe for the first time the emergence of a bystander de novo natural alloantibody against RBCs in a severe COVID-19 patient, highlighting the extra-follicular humoral response reported in these cases.
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spelling pubmed-96281292022-11-03 De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019 Jeannet, Robin Descazeaud, Alexandra Daix, Thomas Pauthier, Hélène Pascal, Virginie Hantz, Sébastien Cam, Sophie Le Francois, Bruno Feuillard, Jean Lafarge, Xavier J Infect Public Health Short Communication The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the emergence of a de novo natural alloantibody which targeted the M antigen from the MNS blood group on red blood cells (RBC) without evidence of any cross-reaction with SARS-CoV-2 antigens. This IgM lambda alloantibody was unmutated and unswitched. Here, we describe for the first time the emergence of a bystander de novo natural alloantibody against RBCs in a severe COVID-19 patient, highlighting the extra-follicular humoral response reported in these cases. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2022-12 2022-11-02 /pmc/articles/PMC9628129/ /pubmed/36403401 http://dx.doi.org/10.1016/j.jiph.2022.10.025 Text en © 2022 Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Jeannet, Robin
Descazeaud, Alexandra
Daix, Thomas
Pauthier, Hélène
Pascal, Virginie
Hantz, Sébastien
Cam, Sophie Le
Francois, Bruno
Feuillard, Jean
Lafarge, Xavier
De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019
title De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019
title_full De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019
title_fullStr De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019
title_full_unstemmed De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019
title_short De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019
title_sort de novo natural anti-m alloantibody emergence in severe coronavirus disease 2019
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628129/
https://www.ncbi.nlm.nih.gov/pubmed/36403401
http://dx.doi.org/10.1016/j.jiph.2022.10.025
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