Fever temperatures modulate intraprotein dynamics and enhance the binding affinity between monoclonal antibodies and the spike protein from SARS-CoV-2

Fever is a typical symptom of most infectious diseases. While prolonged fever may be clinically undesirable, mild reversible fever (<39℃, 312 K) can potentiate the immune responses against pathogens. Here, using molecular dynamics and free energy calculations, we investigated the effect of febril...

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Detalles Bibliográficos
Autores principales: Kim, Dong Gun, Kim, Hak Sung, Choi, Yoonjoo, Stan, Razvan Costin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628194/
https://www.ncbi.nlm.nih.gov/pubmed/36345436
http://dx.doi.org/10.1016/j.csbj.2022.10.045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628194/
https://www.ncbi.nlm.nih.gov/pubmed/36345436
http://dx.doi.org/10.1016/j.csbj.2022.10.045

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