Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

Type-I interferons (IFN-I) are critical mediators of innate control of viral infections, but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, and for the first time, IFN-I signaling was modulated in rhesus macaques (RMs) prior to and during...

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Detalles Bibliográficos
Autores principales: Hoang, Timothy N., Viox, Elise G., Upadhyay, Amit A., Strongin, Zachary, Tharp, Gregory K., Pino, Maria, Nchioua, Rayhane, Hirschenberger, Maximilian, Gagne, Matthew, Nguyen, Kevin, Harper, Justin L., Marciano, Shir, Boddapati, Arun K., Pellegrini, Kathryn L., Tisoncik-Go, Jennifer, Whitmore, Leanne S., Karunakaran, Kirti A., Roy, Melissa, Kirejczyk, Shannon, Curran, Elizabeth H., Wallace, Chelsea, Wood, Jennifer S., Connor-Stroud, Fawn, Kasturi, Sudhir P., Levit, Rebecca D., Gale, Michael, Vanderford, Thomas H., Silvestri, Guido, Busman-Sahay, Kathleen, Estes, Jacob D., Vaccari, Monica, Douek, Daniel C., Sparrer, Konstantin M.J., Kirchhoff, Frank, Johnson, R. Paul, Schreiber, Gideon, Bosinger, Steven E., Paiardini, Mirko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628196/
https://www.ncbi.nlm.nih.gov/pubmed/36324810
http://dx.doi.org/10.1101/2022.10.21.512606

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