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Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants
The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs(1–3), but also revealed how quickly viral escape can curtail effective options(4,5). With the emergence of the SARS-CoV-2 Omicron variant in late 2021, many clinically used antibody drug pro...
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