Chimeric mRNA-based COVID-19 vaccine induces protective immunity against Omicron and Delta variants

The emerging SARS-CoV-2 variants of concern (VOCs) exhibit enhanced transmission and immune escape, reducing the effectiveness of currently approved mRNA vaccines. To achieve wider coverage of VOCs, we first constructed a cohort of mRNAs harboring a furin cleavage mutation in the spike (S) protein o...

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Detalles Bibliográficos
Autores principales: Hu, Qidong, Zhao, Ying, Shaabani, Namir, Lyu, Xiaoxuan, Powers, Colin, Sun, Haotian, Cruz, Vincent, Stegman, Karen, Xu, Jia, Fossier, Amber, Huang, Yu, Ho, Giang, Kao, Yi, Wang, Zhihao, Wang, Zhenping, Hu, Yue, Zheng, Yi, Kyaw, Lilian, Zuluaga, Cipriano, Wang, Hua, Pei, Hong, Allen, Robert, Xie, Hui, Ji, Henry, Chen, Runqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628198/
https://www.ncbi.nlm.nih.gov/pubmed/36345542
http://dx.doi.org/10.1016/j.omtn.2022.10.021

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