A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we performed single-nucleus RNA-seq and spatial transcriptomic profiling of livers from 17 COVID-19 decede...

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Autores principales: Pita-Juarez, Yered, Karagkouni, Dimitra, Kalavros, Nikolaos, Melms, Johannes C., Niezen, Sebastian, Delorey, Toni M., Essene, Adam L, Brook, Olga R., Pant, Deepti, Skelton-Badlani, Disha, Naderi, Pourya, Huang, Pinzhu, Pan, Liuliu, Hether, Tyler, Andrews, Tallulah S., Ziegler, Carly G.K., Reeves, Jason, Myloserdnyy, Andriy, Chen, Rachel, Nam, Andy, Phelan, Stefan, Liang, Yan, Amin, Amit Dipak, Biermann, Jana, Hibshoosh, Hanina, Veregge, Molly, Kramer, Zachary, Jacobs, Christopher, Yalcin, Yusuf, Phillips, Devan, Slyper, Michal, Subramanian, Ayshwarya, Ashenberg, Orr, Bloom-Ackermann, Zohar, Tran, Victoria M., Gomez, James, Sturm, Alexander, Zhang, Shuting, Fleming, Stephen J., Warren, Sarah, Beechem, Joseph, Hung, Deborah, Babadi, Mehrtash, Padera, Robert F., MacParland, Sonya A., Bader, Gary D., Imad, Nasser, Solomon, Isaac H., Miller, Eric, Riedel, Stefan, Porter, Caroline B.M., Villani, Alexandra-Chloé, Tsai, Linus T.-Y., Hide, Winston, Szabo, Gyongyi, Hecht, Jonathan, Rozenblatt-Rosen, Orit, Shalek, Alex K., Izar, Benjamin, Regev, Aviv, Popov, Yury, Jiang, Z. Gordon, Vlachos, Ioannis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628199/
https://www.ncbi.nlm.nih.gov/pubmed/36324805
http://dx.doi.org/10.1101/2022.10.27.514070

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