Epidermal growth factor induces a trophectoderm lineage transcriptome resembling that of human embryos during reconstruction of blastoids from extended pluripotent stem cells

OBJECTIVES: This study aims to optimize the human extended pluripotent stem cell (EPSC) to trophectoderm (TE)‐like cell induction with addition of EGF and improve the quality of the reconstructing blastoids. MATERIALS AND METHODS: TE‐like cells were differentiated from human EPSCs. RNA‐seq data anal...

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Detalles Bibliográficos
Autores principales: Zhang, Yingying, An, Chenrui, Yu, Yanhong, Lin, Jiajing, Jin, Long, Li, Chaohui, Tan, Tao, Yu, Yang, Fan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628219/
https://www.ncbi.nlm.nih.gov/pubmed/35880490
http://dx.doi.org/10.1111/cpr.13317

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