Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor

The nucleocapsid (N) protein plays critical roles in coronavirus genome transcription and packaging, representing a key target for the development of novel antivirals, and for which structural information on ligand binding is scarce. We used a novel fluorescence polarization assay to identify small...

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Detalles Bibliográficos
Autores principales: Mercaldi, Gustavo Fernando, Bezerra, Eduardo Henrique Salviano, Batista, Fernanda Aparecida Heleno, Tonoli, Celisa Caldana Costa, Soprano, Adriana Santos, Shimizu, Jacqueline Farinha, Nagai, Alice, da Silva, Jaqueline Cristina, Filho, Helder Veras Ribeiro, do Nascimento Faria, Jéssica, da Cunha, Marcos Guilherme, Zeri, Ana Carolina Mattos, Nascimento, Andrey Fabricio Ziem, Proenca-Modena, José Luiz, Bajgelman, Marcio Chaim, Rocco, Silvana Aparecida, Lopes-de-Oliveira, Paulo Sérgio, Cordeiro, Artur Torres, Bruder, Marjorie, Marques, Rafael Elias, Sforça, Mauricio Luis, Franchini, Kleber Gomes, Benedetti, Celso Eduardo, Figueira, Ana Carolina Migliorini, Trivella, Daniela Barretto Barbosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628480/
https://www.ncbi.nlm.nih.gov/pubmed/36323732
http://dx.doi.org/10.1038/s41598-022-22576-4

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