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Characteristics and outcomes of severe COVID-19 in hospitalized patients with cardiovascular diseases in the Amazonian region of Brazil: a retrospective cohort
The northern region of Brazil is already vulnerable to other infectious diseases and it was no different in COVID-19. However, cardiovascular diseases still lead the causes of death. Thus, the objective of this study is to identify the clinical predictors and outcome of severe COVID-19 in hospitaliz...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628483/ https://www.ncbi.nlm.nih.gov/pubmed/36323818 http://dx.doi.org/10.1038/s41598-022-23365-9 |
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author | Sardinha, Daniele Melo de Sá, Carmem Aliandra Freire Rodrigues, Yan Corrêa dos Santos Freitas, Joyce Brodeur, Ketan do Socorro Pompeu de Loiola, Rosane Lima, Karla Valéria Batista de Paula Souza e Guimarães, Ricardo José Lima, Luana Nepomuceno Gondim Costa |
author_facet | Sardinha, Daniele Melo de Sá, Carmem Aliandra Freire Rodrigues, Yan Corrêa dos Santos Freitas, Joyce Brodeur, Ketan do Socorro Pompeu de Loiola, Rosane Lima, Karla Valéria Batista de Paula Souza e Guimarães, Ricardo José Lima, Luana Nepomuceno Gondim Costa |
author_sort | Sardinha, Daniele Melo |
collection | PubMed |
description | The northern region of Brazil is already vulnerable to other infectious diseases and it was no different in COVID-19. However, cardiovascular diseases still lead the causes of death. Thus, the objective of this study is to identify the clinical predictors and outcome of severe COVID-19 in hospitalized patients with and without CVD in this region of the Amazon. A retrospective cohort, referring to the notifications from January 1 to December 31, 2020, including cases confirmed by molecular testing. The study consisted of 9223 confirmed cases for COVID-19. Of these, 6011 (65.17%) did not have cardiovascular disease and 3212 (34.83%) had some cardiovascular disease. The significance of deaths was in the age group of < 1 to 59 CVD carriers (< 0.001). Predictor of mortality were invasive ventilation for patients with CVD, (OR 23,688 CI 18,180–30,866), followed by chronic kidney disease (OR 2442 CI 1568–3740), dyspnea (OR 2312 CI 1817–3941), respiratory distress (OR 1523 CI 1210–2919), cough (OR 1268 CI 1005–1599), Lower oxygen saturation 95% (OR 1281 CI 1039–1579), diabetes mellitus (OR 1267 CI 1050–1528) and age (OR 1051 CI 1044–1058). Carriers of CVD had a lower survival rate (< 0.0001). The order of the predictors of death differed among the non-carriers, as well as the high odds ratio in the predictors of CVD, only cough was an independent predictor. The age group under 59 years was associated with deaths. We also show the shorter survival in CVD carriers, as well as the higher cardiovascular morbidity rate than other studies in the literature. |
format | Online Article Text |
id | pubmed-9628483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96284832022-11-02 Characteristics and outcomes of severe COVID-19 in hospitalized patients with cardiovascular diseases in the Amazonian region of Brazil: a retrospective cohort Sardinha, Daniele Melo de Sá, Carmem Aliandra Freire Rodrigues, Yan Corrêa dos Santos Freitas, Joyce Brodeur, Ketan do Socorro Pompeu de Loiola, Rosane Lima, Karla Valéria Batista de Paula Souza e Guimarães, Ricardo José Lima, Luana Nepomuceno Gondim Costa Sci Rep Article The northern region of Brazil is already vulnerable to other infectious diseases and it was no different in COVID-19. However, cardiovascular diseases still lead the causes of death. Thus, the objective of this study is to identify the clinical predictors and outcome of severe COVID-19 in hospitalized patients with and without CVD in this region of the Amazon. A retrospective cohort, referring to the notifications from January 1 to December 31, 2020, including cases confirmed by molecular testing. The study consisted of 9223 confirmed cases for COVID-19. Of these, 6011 (65.17%) did not have cardiovascular disease and 3212 (34.83%) had some cardiovascular disease. The significance of deaths was in the age group of < 1 to 59 CVD carriers (< 0.001). Predictor of mortality were invasive ventilation for patients with CVD, (OR 23,688 CI 18,180–30,866), followed by chronic kidney disease (OR 2442 CI 1568–3740), dyspnea (OR 2312 CI 1817–3941), respiratory distress (OR 1523 CI 1210–2919), cough (OR 1268 CI 1005–1599), Lower oxygen saturation 95% (OR 1281 CI 1039–1579), diabetes mellitus (OR 1267 CI 1050–1528) and age (OR 1051 CI 1044–1058). Carriers of CVD had a lower survival rate (< 0.0001). The order of the predictors of death differed among the non-carriers, as well as the high odds ratio in the predictors of CVD, only cough was an independent predictor. The age group under 59 years was associated with deaths. We also show the shorter survival in CVD carriers, as well as the higher cardiovascular morbidity rate than other studies in the literature. Nature Publishing Group UK 2022-11-02 /pmc/articles/PMC9628483/ /pubmed/36323818 http://dx.doi.org/10.1038/s41598-022-23365-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sardinha, Daniele Melo de Sá, Carmem Aliandra Freire Rodrigues, Yan Corrêa dos Santos Freitas, Joyce Brodeur, Ketan do Socorro Pompeu de Loiola, Rosane Lima, Karla Valéria Batista de Paula Souza e Guimarães, Ricardo José Lima, Luana Nepomuceno Gondim Costa Characteristics and outcomes of severe COVID-19 in hospitalized patients with cardiovascular diseases in the Amazonian region of Brazil: a retrospective cohort |
title | Characteristics and outcomes of severe COVID-19 in hospitalized patients with cardiovascular diseases in the Amazonian region of Brazil: a retrospective cohort |
title_full | Characteristics and outcomes of severe COVID-19 in hospitalized patients with cardiovascular diseases in the Amazonian region of Brazil: a retrospective cohort |
title_fullStr | Characteristics and outcomes of severe COVID-19 in hospitalized patients with cardiovascular diseases in the Amazonian region of Brazil: a retrospective cohort |
title_full_unstemmed | Characteristics and outcomes of severe COVID-19 in hospitalized patients with cardiovascular diseases in the Amazonian region of Brazil: a retrospective cohort |
title_short | Characteristics and outcomes of severe COVID-19 in hospitalized patients with cardiovascular diseases in the Amazonian region of Brazil: a retrospective cohort |
title_sort | characteristics and outcomes of severe covid-19 in hospitalized patients with cardiovascular diseases in the amazonian region of brazil: a retrospective cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628483/ https://www.ncbi.nlm.nih.gov/pubmed/36323818 http://dx.doi.org/10.1038/s41598-022-23365-9 |
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